Antibacterial effects of Brazilian and Bulgarian propolis and synergistic effects with antibiotics acting on the bacterial DNA and folic acid

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dc.contributor.authorOrsi, Ricardo de Oliveira [UNESP]
dc.contributor.authorFernandes, A. [UNESP]
dc.contributor.authorBankova, V.
dc.contributor.authorSforcin, J. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionBulgarian Acad Sci
dc.date.accessioned2013-09-30T18:38:13Z
dc.date.accessioned2014-05-20T13:41:14Z
dc.date.available2013-09-30T18:38:13Z
dc.date.available2014-05-20T13:41:14Z
dc.date.issued2012-01-01
dc.description.abstractPropolis is a honeybee product that has been used since ancient times because of its therapeutic effects. It can be used in the development of alternative therapies for the treatment of many diseases, and because propolis shows antibacterial action, this work was carried out in order to investigate a possible synergism between propolis and antibiotics acting on DNA (ciprofloxacin and norfloxacin) and on the metabolism (cotrimoxazole) against Salmonella Typhi. Propolis samples collected in Brazil and Bulgaria were compared in these assays, and the synergism was investigated by using 1/2 and 1/4 of the minimal inhibitory concentration for propolis and antibiotics, evaluating the number of viable cells according to the incubation time. Brazilian and Bulgarian propolis showed antibacterial activity, but no synergistic effects with the three tested antibiotics were seen. Previous works by our laboratory have revealed that propolis has synergistic effects with antibiotics, acting on the bacterial wall and ribosome, but it does not seem to interact with antibiotics acting on DNA or folic acid, and only a bacteriostatic action was seen in these assay conditions.en
dc.description.affiliationUNESP, Sch Vet Med & Anim Husb, Dept Anim Prod & Explorat, Botucatu, SP, Brazil
dc.description.affiliationUNESP, Dept Microbiol & Immunol, Biosci Inst, Botucatu, SP, Brazil
dc.description.affiliationBulgarian Acad Sci, Ctr Phytochem, Inst Organ Chem, BU-1113 Sofia, Bulgaria
dc.description.affiliationUnespUNESP, Sch Vet Med & Anim Husb, Dept Anim Prod & Explorat, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Microbiol & Immunol, Biosci Inst, Botucatu, SP, Brazil
dc.format.extent344-349
dc.identifierhttp://dx.doi.org/10.1080/14786411003754355
dc.identifier.citationNatural Product Research. Abingdon: Taylor & Francis Ltd, v. 26, n. 4, p. 344-349, 2012.
dc.identifier.doi10.1080/14786411003754355
dc.identifier.issn1478-6419
dc.identifier.urihttp://hdl.handle.net/11449/14289
dc.identifier.wosWOS:000302311600007
dc.language.isoeng
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.relation.ispartofjcr1.928
dc.relation.ispartofsjr0,671
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectpropolisen
dc.subjectantimicrobial activityen
dc.subjectsynergistic effectsen
dc.titleAntibacterial effects of Brazilian and Bulgarian propolis and synergistic effects with antibiotics acting on the bacterial DNA and folic aciden
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dcterms.rightsHolderTaylor & Francis Ltd
unesp.author.orcid0000-0001-8099-8277[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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Artigos - Produção Animal - FMVZ
Artigos - Microbiologia e Imunologia - IBB