Producing xylan/Eudragit (R) S100-based microparticles by chemical and physico-mechanical approaches as carriers for 5-aminosalicylic acid

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dc.contributor.authorSilva, Acarilia Eduardo
dc.contributor.authorOliveira, Elquio Eleamen
dc.contributor.authorSalgado Gomes, Monique C.
dc.contributor.authorMarcelino, Henrique Rodrigues
dc.contributor.authorHolanda Silva, Karen C.
dc.contributor.authorSouza, Bartolomeu Santos
dc.contributor.authorNagashima-, Toshiyuki
dc.contributor.authorAyala, Alejandro Pedro
dc.contributor.authorOliveira, Anselmo Gomes de [UNESP]
dc.contributor.authorTabosa do Egito, Eryvaldo Socrates
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)
dc.contributor.institutionUniv Paris 11
dc.contributor.institutionUEPB
dc.contributor.institutionUniv Florida
dc.contributor.institutionUniversidade Federal de Campina Grande (UFCG)
dc.contributor.institutionUniversidade Federal do Ceará (UFC)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:11:43Z
dc.date.available2014-12-03T13:11:43Z
dc.date.issued2013-01-01
dc.description.abstractXylan is a biopolymer found in a variety of cell wall plants. Eudragit (R) S-100 (ES100), a pH-dependent polymer, is used as a coating material in gastroresistant delivery systems. In this study, microparticles based on both polymers were produced by interfacial cross-linking polymerisation and/or spray-drying technique in order to investigate feasibility and stability of the systems. Size and morphology of the microparticles were characterised by optical and SEM while FT-IR, thermal analysis (TG/DTA), and X-ray diffraction (XRD) evaluated the drug-polymer interactions and the thermal behaviour of the systems. FT-IR confirmed the absence of chemical interaction between the polymers. TG/DTA analysis showed a higher stability for spray-dried microparticles and XRD data proved the amorphous feature of both carriers. The results reveal that xylan/ES100 microparticles can be produced by chemical or physico-mechanical ways, the latter being the best option due to the lack of toxic cross-linking agents and easy scale-up.en
dc.description.affiliationUniv Fed Rio Grande do Norte, Programa Posgrad Ciencias Saude PPgCSa, BR-59094450 Natal, RN, Brazil
dc.description.affiliationUniv Paris 11, Inst Galien Paris Sud, F-92296 Chatenay Malabry, France
dc.description.affiliationUEPB, Ctr Ciencias Biol & Sociais Aplicadas, Lab Sintese & Vetorizacao Mol, Joao Pessoa, Paraiba, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte, Dept Farm DFAR, BR-59094450 Natal, RN, Brazil
dc.description.affiliationUniv Florida, Dept Pharm, Gainesville, FL USA
dc.description.affiliationUFCG, Ctr Educ & Saude, Cuite, PB, Brazil
dc.description.affiliationUniv Fed Ceara, Dept Fis, Fortaleza, Ceara, Brazil
dc.description.affiliationUNESP, Dept Farmacos & Medicamentos, Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Farmacos & Medicamentos, Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent787-795
dc.identifierhttp://dx.doi.org/10.3109/02652048.2013.788087
dc.identifier.citationJournal Of Microencapsulation. London: Informa Healthcare, v. 30, n. 8, p. 787-795, 2013.
dc.identifier.doi10.3109/02652048.2013.788087
dc.identifier.issn0265-2048
dc.identifier.lattes9114495952533044
dc.identifier.urihttp://hdl.handle.net/11449/113469
dc.identifier.wosWOS:000326194600008
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofJournal of Microencapsulation
dc.relation.ispartofjcr1.793
dc.relation.ispartofsjr0,520
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCross-linkingen
dc.subjectinfrared spectroscopyen
dc.subjectpolymer-biopolymer interactionen
dc.subjectspray-dryingen
dc.subjectthermal analysisen
dc.titleProducing xylan/Eudragit (R) S100-based microparticles by chemical and physico-mechanical approaches as carriers for 5-aminosalicylic aciden
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dcterms.rightsHolderInforma Healthcare
unesp.author.lattes9114495952533044[9]
unesp.author.orcid0000-0002-9247-6780[8]
unesp.author.orcid0000-0002-2180-3991[10]
unesp.author.orcid0000-0002-0107-9940[9]
unesp.author.orcid0000-0002-3625-7786[4]
unesp.author.orcid0000-0002-9247-6780[8]
unesp.author.orcid0000-0002-7214-4455[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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