Protein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinoma

Página do item simplificado
dc.contributor.authorKaminagakura, E. [UNESP]
dc.contributor.authorCaris, A. [UNESP]
dc.contributor.authorCoutinho-Camillo, C.
dc.contributor.authorSoares, F. A.
dc.contributor.authorTakahama-Júnior, A.
dc.contributor.authorKowalski, L. P.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionA.C. Camargo Cancer Centre
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.date.accessioned2018-12-11T16:41:28Z
dc.date.available2018-12-11T16:41:28Z
dc.date.issued2016-06-01
dc.description.abstractThe purpose of this study was to evaluate the expression of the enzymes involved in the biotransformation of tobacco and alcohol. A study group of 41 young patients (≤40 years old) with oral squamous cell carcinoma (OSCC) was compared to 59 control subjects (≥50 years old) with tumours of similar clinical stages and topographies. The immunohistochemical expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 was evaluated using the tissue microarray technique. There was a predominance of males, smokers, and alcohol drinkers in both groups. Most tumours were located in the tongue (43.9% vs. 50.8%), were well-differentiated (63.4% vs. 56.6%), and were in clinical stages III or IV (80.5% vs. 78.0%). No difference was observed in the expression of CYP1A1, ALDH1A1, or ALDH2 between the two groups. CYP1A1 and ALDH2 protein expression had no influence on the prognosis. The immunoexpression of CYP1B1 was significantly higher in the control group than in the young group (P < 0.001). The 5-year relapse-free survival was better in patients with CYP1B1 overexpression vs. protein underexpression (64% vs. 25%; P < 0.05), regardless of age. ALDH1A1 expression improved relapse-free survival in young patients. These results suggest a lower risk of recurrence with increased metabolism of carcinogens by CYP1B1. Further studies involving other genes and proteins are necessary to complement the results of this research.en
dc.description.affiliationDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology Universidade Estadual Paulista Julio de Mesquita Filho - UNESP, Avenida Francisco José Engenheiro Longo 777
dc.description.affiliationBiopathology Program Institute of Science and Technology Universidade Estadual Paulista Julio de Mesquita Filho - UNESP
dc.description.affiliationInternational Research Centre A.C. Camargo Cancer Centre
dc.description.affiliationDepartment of Pathology A.C. Camargo Cancer Centre
dc.description.affiliationDepartment of Specific Formation Universidade Federal Fluminense
dc.description.affiliationDepartment of Head and Neck Surgery and Otorhinolaryngology A.C. Camargo Cancer Centre
dc.description.affiliationUnespDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology Universidade Estadual Paulista Julio de Mesquita Filho - UNESP, Avenida Francisco José Engenheiro Longo 777
dc.description.affiliationUnespBiopathology Program Institute of Science and Technology Universidade Estadual Paulista Julio de Mesquita Filho - UNESP
dc.format.extent706-712
dc.identifierhttp://dx.doi.org/10.1016/j.ijom.2016.02.004
dc.identifier.citationInternational Journal of Oral and Maxillofacial Surgery, v. 45, n. 6, p. 706-712, 2016.
dc.identifier.doi10.1016/j.ijom.2016.02.004
dc.identifier.file2-s2.0-84961130017.pdf
dc.identifier.issn1399-0020
dc.identifier.issn0901-5027
dc.identifier.scopus2-s2.0-84961130017
dc.identifier.urihttp://hdl.handle.net/11449/168484
dc.language.isoeng
dc.relation.ispartofInternational Journal of Oral and Maxillofacial Surgery
dc.relation.ispartofsjr1,137
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectaldehyde dehydrogenase
dc.subjectALDH
dc.subjectCYP
dc.subjectcytochrome P450
dc.subjectoral cancer
dc.subjectsquamous cell carcinoma
dc.subjectyoung age
dc.titleProtein expression of CYP1A1, CYP1B1, ALDH1A1, and ALDH2 in young patients with oral squamous cell carcinomaen
dc.typeArtigo

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
2-s2.0-84961130017.pdf
Tamanho:
1.58 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar

Coleções

Artigos