Evaluation of the analgesic and antiedematogenic activities of Quassia amara bark extract

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dc.contributor.authorToma, W.
dc.contributor.authorGracioso, J. S.
dc.contributor.authorHiruma-Lima, C. A.
dc.contributor.authorAndrade, FDP
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorBrito, ARMS
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:49:43Z
dc.date.available2014-05-20T13:49:43Z
dc.date.issued2003-03-01
dc.description.abstractWe evaluated the possible antiedematogenic, antinociceptive and/or sedative effects of four different extracts obtained from the bark of Quassia amara namely, 70% ethanol (70EtOH), 100% ethanol (100EtOH), dichloromethane (DCM) and hexane extracts (HEX). The oral administration (100, 250 and 500 mg/kg) of these extracts did not show significant effects in any experiment. However, when administered intraperitoneally, the HEX extract decreased the paw edema induced by carrageenan, showed antinociceptive effects on the hot-plate test and on acetic acid-induced writhing, and showed sedative effects on pentobarbital-induced sleep. Naloxone did not reverse the antinociceptive effect of this extract. In conclusion, although the mechanisms are uncertain, the results demonstrated that these effects are apparently related to sedative and muscle relaxant or psychomimetic activities of the HEX extract of the plant. (C) 2002 Elsevier B.V. Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, Dept Fisiol & Biofis, Inst Biol, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Fisiol, Inst Biociencias, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Quim Organ, Inst Quim, Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Fisiol, Inst Biociencias, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Quim Organ, Inst Quim, Araraquara, SP, Brazil
dc.format.extent19-23
dc.identifierhttp://dx.doi.org/10.1016/S0378-8741(02)00334-3
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier Sci Ireland Ltd, v. 85, n. 1, p. 19-23, 2003.
dc.identifier.doi10.1016/S0378-8741(02)00334-3
dc.identifier.issn0378-8741
dc.identifier.lattes3814504901386844
dc.identifier.orcid0000-0002-8645-3777
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/17728
dc.identifier.wosWOS:000181227100004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectQuassia amarapt
dc.subjectantiedematogenic effectpt
dc.subjectantinociceptive effectpt
dc.subjectsedative effectpt
dc.titleEvaluation of the analgesic and antiedematogenic activities of Quassia amara bark extracten
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3814504901386844[3]
unesp.author.orcid0000-0002-8645-3777[3]
unesp.author.orcid0000-0003-3032-2556[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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Artigos - Fisiologia - IBB
Artigos - Química Orgânica - IQ