Cold-acclimation improves cold-tolerance of diabetic rats

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dc.contributor.authorFerro, Jesus A
dc.contributor.authorMacari, Marcos [UNESP]
dc.contributor.authorEizirik, Décio L
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T03:15:39Z
dc.date.available2014-05-27T03:15:39Z
dc.date.issued1987-12-01
dc.description.abstract1. 1. The aim of these experiments was to study the extent to which previous cold-acclimation improves the cold-tolerance of diabetic rats. 2. 2. Alloxan diabetic rats (fasting blood glucose higher than 200mg/dl) were used in the experiments. 3. 3. In Expt. 1, non-cold-acclimated control and diabetic rats were exposed to cold environment (7-9°C), and the percentage of survival calculated during a 12-day experimental period. In Expt. 2, the rats were previously cold-acelimated before alloxan or saline injection (diabetic and control cold-acclimated rats) and the survival rate was also assessed during a 12-day period in the cold. 4. 4. The percentage of survival of the non-cold-acclimated diabetic rats (Expt.l) was 19% compared with 79% of the diabetic cold-acclimated animals (Expt. 2). There were no deaths in the control groups. 5. 5. Cold-acclimated diabetic rats maintained a near-normal thermogenic response after noradrenaline injection. This response was impaired in non-cold-acclimated diabetic rats. 6. 6. The results of these experiments suggest that the enhanced cold-tolerance of diabetic cold-acclimated rats could be related to the increased sympathetic activity and enhanced insulin sensitivity in thermogenic tissues, such as brown fat. © 1987.en
dc.description.affiliationDepartamento de Clínicia Médica Faculdade de Medicina de Ribeirão Preto USP, SP
dc.format.extent425-429
dc.identifierhttp://dx.doi.org/10.1016/0300-9629(87)90057-0
dc.identifier.citationComparative Biochemistry and Physiology -- Part A: Physiology, v. 88, n. 3, p. 425-429, 1987.
dc.identifier.doi10.1016/0300-9629(87)90057-0
dc.identifier.issn0300-9629
dc.identifier.lattes5713558572926669
dc.identifier.scopus2-s2.0-0023505275
dc.identifier.urihttp://hdl.handle.net/11449/63815
dc.language.isoeng
dc.relation.ispartofComparative Biochemistry and Physiology Part A: Physiology
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectnoradrenalin
dc.subjectacclimatization
dc.subjectanimal
dc.subjectbody weight
dc.subjectcold
dc.subjectcomparative study
dc.subjectdrug effect
dc.subjectexperimental diabetes mellitus
dc.subjectmale
dc.subjectpathophysiology
dc.subjectrat
dc.subjectrat strain
dc.subjectreference value
dc.subjectthermoregulation
dc.subjecttime
dc.subjectAcclimatization
dc.subjectAnimal
dc.subjectBody Temperature Regulation
dc.subjectBody Weight
dc.subjectCold
dc.subjectComparative Study
dc.subjectDiabetes Mellitus, Experimental
dc.subjectMale
dc.subjectNorepinephrine
dc.subjectRats
dc.subjectRats, Inbred Strains
dc.subjectReference Values
dc.subjectSupport, Non-U.S. Gov't
dc.subjectTime Factors
dc.titleCold-acclimation improves cold-tolerance of diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes5713558572926669
unesp.author.orcid0000-0002-6850-7145[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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