Influence of nicotine and cotinine impregnation on the first step of periodontal regeneration: clot stabilization

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dc.contributor.authorPinto, Shelon Cristina Souza
dc.contributor.authorLeite, Fabio Renato Manzolli
dc.contributor.authorFontanari, Lucas Amaral
dc.contributor.authorCavassim, Rodrigo
dc.contributor.authorLeite, Amauri Antiqueira
dc.contributor.authorBandéca, Mateus Coelho
dc.contributor.authorBorges, Alvaro Henrique
dc.contributor.authorSampaio, Jose Eduardo Cezar [UNESP]
dc.contributor.institutionUniversidade Estadual de Ponta Grossa (UEPG)
dc.contributor.institutionUniversidade Federal de Pelotas (UFPEL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Ceuma
dc.contributor.institutionUniversidade de Cuiabá (UNIC)
dc.date.accessioned2015-08-06T16:12:53Z
dc.date.available2015-08-06T16:12:53Z
dc.date.issued2013
dc.description.abstractThis study analyzes the clot stabilization on root surfaces of teeth impregnated with cotinine and nicotine and the influence of the scaling in the adhesion of blood components, observing the influence of new exposition to nicotine and/or cotinine after scaling. Fifteen human teeth extracted due to periodontal disease of non-smokers patients were selected and manually scaled. Four dentin blocks were obtained from each tooth (n = 60). Samples received blood application or reimpregnation with nicotine and/or cotinine, depending on the groups. Group 1: PBS immersion + root scaling + blood; group 2: nicotine + root scaling + blood; group 3: nicotine + root scaling + nicotine reapplication + blood; group 4: cotinine + root scaling + blood; group 5: cotinine + root scaling + cotinine reapplication+ blood; group 6: nicotine and cotinine + root scaling + nicotine and cotinine + blood. Samples were kept in 2 ml of each substance for 24 hours. Each group received a blood drop and was analyzed by SEM. The higher amount of blood components was present in teeth exposed to cotinine and the groups submitted to scaling and blood application in comparison with groups that received reapplication of toxic substances after scaling. The greater toxic effect on root dentin surface was after the exposure to nicotine and cotinine. Results suggest that periodontal healing may be delayed in smokers due to the direct inhibition of clot stabilization on the root surface when nicotine and cotinine are present concomitantly.en
dc.description.affiliationUniversidade Estadual de Ponta Grossa, Departamento de Odontologia
dc.description.affiliationUniversidade Federal de Pelotas, Departamento de Semiologia e Clínicas
dc.description.affiliationUniversidade Ceuma, Departamento de Pós-graduação em Odontologia
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Diagnóstico e Cirurgia, Faculdade de Odontologia de Araraquara
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara
dc.format.extent1044-1048
dc.identifierhttp://www.jaypeejournals.com/eJournals/Abstract.aspx?id=5824&AID=24&num=9
dc.identifier.citationThe Journal of Contemporary Dental Practice, v. 14, n. 6, p. 1044-1048, 2013.
dc.identifier.doi10.5005/jp-journals-10024-1448
dc.identifier.issn1526-3711
dc.identifier.lattes5001834460012280
dc.identifier.lattes0652077402764417
dc.identifier.lattes7713504467337236
dc.identifier.lattes9531839078426485
dc.identifier.urihttp://hdl.handle.net/11449/125704
dc.language.isoeng
dc.relation.ispartofThe Journal of Contemporary Dental Practice
dc.relation.ispartofsjr0,263
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectClot stabilizationen
dc.subjectPeriodontal regenerationen
dc.subjectNicotineen
dc.subjectCotinineen
dc.titleInfluence of nicotine and cotinine impregnation on the first step of periodontal regeneration: clot stabilizationen
dc.typeArtigo
unesp.author.lattes5001834460012280
unesp.author.lattes0652077402764417
unesp.author.lattes7713504467337236
unesp.author.lattes9531839078426485
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentDiagnóstico e Cirurgiapt
unesp.departmentAnálises Clínicaspt

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Artigos - Diagnóstico e Cirurgia - FOAR
Artigos - Análises Clínicas - FCFAR