Distinct β-glucan molecules modulates differently the circulating cortisol levels and innate immune responses in matrinxã (Brycon amazonicus)

Página do item simplificado
dc.contributor.authorFranco Montoya, Luz Natalia [UNESP]
dc.contributor.authorFavero, Gisele Cristina [UNESP]
dc.contributor.authorZanuzzo, Fabio Sabbadin [UNESP]
dc.contributor.authorUrbinati, Elisabeth Criscuolo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionPereira
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionMemorial University of Newfoundland
dc.date.accessioned2018-12-11T17:22:45Z
dc.date.available2018-12-11T17:22:45Z
dc.date.issued2018-12-01
dc.description.abstractThis study investigated the effects of two β-glucan molecules with different purities and isolated by different biotechnological processes on the immune response of matrinxã (Brycon amazonicus) prior and after challenge with Aeromonas hydrophila. In this sense, we evaluated serum cortisol and plasma glucose levels, the number of leukocytes (lymphocytes, neutrophils and monocytes), as well as the respiratory activity of leukocytes prior to, 6 and 24 h post infection (hpi). During 15 days, fish were fed with diets containing 0.1% of two β-glucans (β-G 1 and β-G 2, with 71 and 62% of purity, respectively) and then submitted to challenge. Results were compared with a positive control group fed with a β-glucan-free diet. A negative control group, also fed with β-glucan-free diet but inoculated with PBS, was established to evaluate the effect of handling during injection. Our results showed that different β-glucans affected differently the biological responses of matrinxã. The βG 2 modulated the cortisol profile prior to and after the acute infection with A. hydrophila, and increased the mobilization and activity of leukocytes. The infection promoted lymphopenia at 6 hpi and both β-glucans increased the circulating lymphocyte population 24 hpi. Moreover, the β-G 2 prevented the infection-induced neutrophilia at 6 and 24 hpi. Finally, the β-G 2 caused a marked increase in the circulating monocytes prior to infection, and a reduction at 6 hpi that was reversed at 24 hpi. In summary, our study demonstrates that β-G 2 was more efficient on the induction of the cell-mediate immunity in matrinxã.en
dc.description.affiliationUniversidade Estadual Paulista (Unesp) Faculdade de Ciências Agrárias e Veterinárias
dc.description.affiliationUniversidade Estadual Paulista (Unesp) Centro de Aquicultura da Unesp
dc.description.affiliationUniversidad Tecnológica de Pereira Facultad de Ciencias de la Salud Departamento de Ciencias Basicas Pereira
dc.description.affiliationUniversidade Federal de Minas Gerais (UFMG) Campus Pampulha
dc.description.affiliationMemorial University of Newfoundland Department of Ocean Sciences
dc.description.affiliationUnespUniversidade Estadual Paulista (Unesp) Faculdade de Ciências Agrárias e Veterinárias
dc.description.affiliationUnespUniversidade Estadual Paulista (Unesp) Centro de Aquicultura da Unesp
dc.description.sponsorshipAsociación Universitaria Iberoamericana de Postgrado
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipIdAsociación Universitaria Iberoamericana de Postgrado: 151185-1
dc.format.extent314-320
dc.identifierhttp://dx.doi.org/10.1016/j.fsi.2018.09.042
dc.identifier.citationFish and Shellfish Immunology, v. 83, p. 314-320.
dc.identifier.doi10.1016/j.fsi.2018.09.042
dc.identifier.file2-s2.0-85053445845.pdf
dc.identifier.issn1095-9947
dc.identifier.issn1050-4648
dc.identifier.scopus2-s2.0-85053445845
dc.identifier.urihttp://hdl.handle.net/11449/176851
dc.language.isoeng
dc.relation.ispartofFish and Shellfish Immunology
dc.relation.ispartofsjr1,126
dc.relation.ispartofsjr1,126
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCell-mediated immunity
dc.subjectEarly defense
dc.subjectImmunostimulation
dc.subjectWhite blood cells
dc.titleDistinct β-glucan molecules modulates differently the circulating cortisol levels and innate immune responses in matrinxã (Brycon amazonicus)en
dc.typeArtigo
unesp.author.orcid0000-0001-6623-8095 0000-0001-6623-8095[4]

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
2-s2.0-85053445845.pdf
Tamanho:
1.18 MB
Formato:
Adobe Portable Document Format
Descrição:
Baixar

Coleções

Jaboticabal - CAUNESP - Centro de Aquicultura da Unesp