Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens

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dc.contributor.authorFernandes, Daniara Cristina [UNESP]
dc.contributor.authorRegasini, Luis Octávio [UNESP]
dc.contributor.authorVellosa, José Carlos Rebuglio [UNESP]
dc.contributor.authorPauletti, Patrícia Mendonça [UNESP]
dc.contributor.authorCastro-Gamboa, Ian [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorOliveira, Olga Maria Mascarenhas [UNESP]
dc.contributor.authorSilva, Dulce Helena Siqueira [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:32Z
dc.date.available2014-05-27T11:23:32Z
dc.date.issued2008-05-19
dc.description.abstractTwo new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-β-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-β-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC 50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox®. © 2008 Pharmaceutical Society of Japan.en
dc.description.affiliationDepartment of Organic Chemistry Institute of Chemistry UNESP-São Paulo State University, CP 355, Araraquara, SP, CEP 14801-970
dc.description.affiliationDepartment of Biochemistry and Chemical Technology Institute of Chemistry UNESP-São Paulo State University, CP 355, Araraquara, SP, CEP 14801-970
dc.description.affiliationUnespDepartment of Organic Chemistry Institute of Chemistry UNESP-São Paulo State University, CP 355, Araraquara, SP, CEP 14801-970
dc.description.affiliationUnespDepartment of Biochemistry and Chemical Technology Institute of Chemistry UNESP-São Paulo State University, CP 355, Araraquara, SP, CEP 14801-970
dc.format.extent723-726
dc.identifierhttp://dx.doi.org/10.1248/cpb.56.723
dc.identifier.citationChemical and Pharmaceutical Bulletin, v. 56, n. 5, p. 723-726, 2008.
dc.identifier.doi10.1248/cpb.56.723
dc.identifier.issn0009-2363
dc.identifier.issn1347-5223
dc.identifier.lattes4484083685251673
dc.identifier.lattes4702004904231248
dc.identifier.lattes0992736452764550
dc.identifier.orcid0000-0002-1516-7765
dc.identifier.scopus2-s2.0-43449110138
dc.identifier.urihttp://hdl.handle.net/11449/70410
dc.identifier.wosWOS:000256184200021
dc.language.isoeng
dc.relation.ispartofChemical and Pharmaceutical Bulletin
dc.relation.ispartofjcr1.258
dc.relation.ispartofsjr0,364
dc.relation.ispartofsjr0,364
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntioxidant
dc.subjectFlavone
dc.subjectMyeloperoxidase
dc.subjectPterogyne nitens
dc.subjectRadical scavenging
dc.subjectflavone derivative
dc.subjectglucoside
dc.subjectmyeloperoxidase
dc.subjectnitensoside a
dc.subjectnitensoside b
dc.subjectpedalitin
dc.subjectpedalitin 6 o beta glucopyranoside
dc.subjectsorbifolin
dc.subjectsorbifolin 6 o beta glucopyranoside
dc.subjectcontrolled study
dc.subjectdrug inhibition
dc.subjectdrug structure
dc.subjectIC 50
dc.subjectlegume
dc.subjectnonhuman
dc.subjectnuclear magnetic resonance
dc.subjectBenzothiazoles
dc.subjectEnzyme Inhibitors
dc.subjectFabaceae
dc.subjectFlavones
dc.subjectFree Radical Scavengers
dc.subjectGlucosides
dc.subjectMagnetic Resonance Spectroscopy
dc.subjectPeroxidase
dc.subjectPicrates
dc.subjectPlant Leaves
dc.subjectSulfonic Acids
dc.titleMyeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitensen
dc.typeArtigo
dcterms.licensehttp://bpb.pharm.or.jp/document/transfer.pdf
unesp.author.lattes4484083685251673
unesp.author.lattes4702004904231248[8]
unesp.author.lattes0992736452764550
unesp.author.orcid0000-0002-1516-7765[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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