Concentrações séricas e peritoneal de proteínas de fase aguda em equinos submetidos à endotoxemia experimental, tratados ou não com lidocaína

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dc.contributor.advisorFeitosa, Francisco Leydson Formiga [UNESP]
dc.contributor.authorYanaka, Rodrigo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-04-09T12:28:12Z
dc.date.available2015-04-09T12:28:12Z
dc.date.issued2013-02-08
dc.description.abstractEndotoxins are often found in high concentration in the peritoneal fluid from horses with acute gastrointestinal disease and blood of septicemic foals. The conditions mentioned earlier can lead to inflammatory processes and cause changes in the concentrations of acute phase proteins. The objectives of this study were to determine by means of polyacrylamide gel electrophoresis (SDS-PAGE), the concentrations of acute phase proteins (transferrin, ceruloplasmin, albumin, haptoglobin and acid glycoprotein) in serum and peritoneal fluid of horses submitted to experimental endotoxemia and evaluate the possible effects of the administration of lidocaine on the production of these proteins after intraperitoneal injection of endotoxin in these animals. To this end, 12 animals were distributed in two groups, control which was treated with 0.9% NaCl solution and the experimental which was treated with continuous infusion for 6 hours of 2% lidocaine solution. It is concluded that in this experimental model the intraperitoneal administration of endotoxin caused an increase in the concentrations of peritoneal transferrin, ceruloplasmin and haptoglobin in the control group, of albumin in both groups, and the acid glycoprotein in the group treated with infusion of lidocaine. However, the absence of changes in the concentrations of serum ceruloplasmin, serum albumin, haptoglobin and acidic glycoprotein indicate that the amount of the circulatory endotoxin was not enough to alter serum concentrations of these proteins. The continuous infusion of lidocaine interfered in peritoneal acute phase proteins values and had an anti-endotoxemic effecten
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2009/15683-0
dc.format.extent41 f.
dc.identifier.aleph000814587
dc.identifier.capes33004021075P8
dc.identifier.citationYANAKA, Rodrigo. Concentrações séricas e peritoneal de proteínas de fase aguda em equinos submetidos à endotoxemia experimental, tratados ou não com lidocaína. 2013. 41 f. Tese (doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária, 2013.
dc.identifier.file000814587.pdf
dc.identifier.lattes6320587871778038
dc.identifier.urihttp://hdl.handle.net/11449/121937
dc.language.isopor
dc.publisherUniversidade Estadual Paulista (Unesp)
dc.rights.accessRightsAcesso aberto
dc.sourceAleph
dc.subjectEndotoxinapt
dc.subjectEletroforese em gelpt
dc.subjectEquinopt
dc.subjectLidocainapt
dc.subjectEndotoxemiapt
dc.subjectTransferrinapt
dc.subjectPolyacrylamide gel electrophoresispt
dc.titleConcentrações séricas e peritoneal de proteínas de fase aguda em equinos submetidos à endotoxemia experimental, tratados ou não com lidocaínapt
dc.typeTese de doutorado
unesp.author.lattes6320587871778038
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatubapt
unesp.graduateProgramCiência Animal - FMVApt
unesp.knowledgeAreaFisiopatologia Médica e Cirurgicapt
unesp.researchAreaFisiopatologia médica e cirurgica de grandes animaispt

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