Cytotoxic Clerodane Diterpenoids from Casearia obliqua

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dc.contributor.authorVieira Junior, Gerardo Magela [UNESP]
dc.contributor.authorGoncalves, Tiago de Oliveira [UNESP]
dc.contributor.authorRegasini, Luis O. [UNESP]
dc.contributor.authorPinheiro Ferreira, Paulo M.
dc.contributor.authorPessoa, Claudia do O.
dc.contributor.authorCosta Lotufo, Leticia V.
dc.contributor.authorTorres, Roseli Buzanelli
dc.contributor.authorBoralle, Nivaldo [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorCavalheiro, Alberto José [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Ceará (UFC)
dc.contributor.institutionInstituto Agronômico (IAC)
dc.date.accessioned2014-05-20T14:20:12Z
dc.date.available2014-05-20T14:20:12Z
dc.date.issued2009-10-01
dc.description.abstractA crude bioactive EtOH extract of the twigs of Casearia obliqua afforded two new clerodane diterpenes, caseobliquins A (1) and B (2). Additionally, bioactivity-directed fractionation on a bioactive hexane extract of the leaves from this species led. to the isolation of the known clerodane diterpenes rel-6 beta-hydroxyzuelanin-2 beta-benzoate and rel-2 alpha-hydroxyzuelanin-6 beta-benzoate (3 and 4) as a mixture and 2 beta-hydroxyzuelanin-6 beta-cinnamate (5). The structures of the new clerodanes 1 and 2 were established on the basis of their 1D and 2D NMR spectroscopic data, and the new compound I and the known substance 5 had their absolute configurations determined by circular dichroism spectroscopy. The cytotoxicity of several of the compounds isolated was evaluated against a small panel of human tumor cell lines.en
dc.description.affiliationSão Paulo State Univ, UNESP, Inst Chem, Nuclei Bioassay Biosynth & Ecophysiol Nat Prod Nu, BR-1480197 Araraquara, SP, Brazil
dc.description.affiliationUniversidade Federal do Ceará (UFC), Dept Fisiol & Farmacol, LOE, BR-60430270 Fortaleza, Ceara, Brazil
dc.description.affiliationInst Agron Estado São Paulo, Nucleo Jardim Bot, BR-13020902 Campinas, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Inst Chem, Nuclei Bioassay Biosynth & Ecophysiol Nat Prod Nu, BR-1480197 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipBiota Instituto, Virtual da Biodiversidade
dc.description.sponsorshipIdFAPESP: 03/02176-7
dc.format.extent1847-1850
dc.identifierhttp://dx.doi.org/10.1021/np9004079
dc.identifier.citationJournal of Natural Products. Washington: Amer Chemical Soc, v. 72, n. 10, p. 1847-1850, 2009.
dc.identifier.doi10.1021/np9004079
dc.identifier.issn0163-3864
dc.identifier.urihttp://hdl.handle.net/11449/26065
dc.identifier.wosWOS:000271950400019
dc.language.isoeng
dc.publisherAmer Chemical Soc
dc.relation.ispartofJournal of Natural Products
dc.relation.ispartofjcr3.885
dc.relation.ispartofsjr1,368
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleCytotoxic Clerodane Diterpenoids from Casearia obliquaen
dc.typeArtigo
dcterms.licensehttp://pubs.acs.org/page/policy/nih/index.html
dcterms.rightsHolderAmer Chemical Soc
unesp.author.lattes2518006820764120[10]
unesp.author.orcid0000-0001-8214-9957[10]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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