Piroxicam encapsulated in liposomes: Characterization and in vivo evaluation of topical anti-inflammatory effect

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dc.contributor.authorCanto, G. S.
dc.contributor.authorDalmora, S. L.
dc.contributor.authorOliveira, Anselmo Gomes de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.date.accessioned2014-05-20T13:24:37Z
dc.date.available2014-05-20T13:24:37Z
dc.date.issued1999-01-01
dc.description.abstractLiposomes of soya phosphatidylcholine, cholesterol, and stearylamine (molar ratio 6/3/1) and 0.1% alpha-tocopherol were prepared by the extrusion of multilamellar vesicles through 0.2-mu m polycarbonate membrane. Liposomes were characterized by electron transmission microscopy, and the mean structure diameter was 278 nm. The encapsulation efficiency obtained was 12.73%. The topical anti-inflammatory effect was evaluated in vivo by the cotton pellet granuloma method. We analyzed free piroxicam at 4 mg/kg, piroxicam encapsulated in liposomes added to 1.5% hydroxyethylcellulose (HEC) gel at 1.6 mg/kg, and piroxicam encapsulated in liposomes added to HEC gel at 4 mg/kg; the inhibition of inflammation obtained was 21.1%, 32.8%, and 47.4%, respectively. These results showed that the encapsulation of piroxicam produced an increase of topical anti-inflammatory effect, suggesting that the inhibition of inflammation can be obtained with lower drug concentrations.en
dc.description.affiliationUNESP, Fac Ciências Farmaceut, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUFSM, Ctr Ciências Saude, Dept Farm Ind, BR-97119900 Santa Maria Imbaro, RS, Brazil
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil
dc.format.extent1235-1239
dc.identifierhttp://dx.doi.org/10.1081/DDC-100102293
dc.identifier.citationDrug Development and Industrial Pharmacy. New York: Marcel Dekker Inc., v. 25, n. 12, p. 1235-1239, 1999.
dc.identifier.doi10.1081/DDC-100102293
dc.identifier.issn0363-9045
dc.identifier.lattes9114495952533044
dc.identifier.urihttp://hdl.handle.net/11449/7694
dc.identifier.wosWOS:000084610500002
dc.language.isoeng
dc.publisherMarcel Dekker Inc
dc.relation.ispartofDrug Development and Industrial Pharmacy
dc.relation.ispartofjcr1.883
dc.relation.ispartofsjr0,519
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titlePiroxicam encapsulated in liposomes: Characterization and in vivo evaluation of topical anti-inflammatory effecten
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/page/resources/authors
dcterms.rightsHolderMarcel Dekker Inc
unesp.author.lattes9114495952533044[3]
unesp.author.orcid0000-0002-0107-9940[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Artigos - Fármacos e Medicamentos - FCFAR