Efeitos da polpa do fruto de annona crassiflora mart., nos parâmetros bioquímicos e na carcinogênese de colon de ratos

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dc.contributor.authorVenâncio, Vinícius Paula
dc.contributor.authorFerreira, Eric Batista
dc.contributor.authorBrigagão, Maísa Ribeiro Pereira Lima
dc.contributor.authorPaula, Fernanda Borges de Araújo
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.authorAzevedo, Luciana
dc.contributor.institutionGabriel Monteiro da Silva
dc.contributor.institutionInstituto de Ciências Exatas
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)
dc.date.accessioned2014-05-27T11:29:53Z
dc.date.available2014-05-27T11:29:53Z
dc.date.issued2013-07-01
dc.description.abstractA. crassiflora Mart. a Brazilian savannah fruit, is a source of phytochemical compounds that possess a wide array of biological activities, including free radical scavenging. This native fruit proved to potentialize the mutagenic process in previous in vivo investigations. The aim of the present study was to investigate the effects of A. crassiflora Mart. pulp intake on colonic cell proliferation and on the development of Aberrant Crypt Foci (ACF) in male Wistar rats. The animals were fed with either a commercial diet or a diet supplemented with A. crassiflora Mart. pulp mixed in 1%, 10% or 20% (w/w) for 4 weeks or 20 weeks. The carcinogen 1,2-dimethylhydrazine dihydrochloride (4 doses, 40 mg kg-1 each) was used to induce colonic ACF. After euthanasia, the blood, liver and colon samples were collected for biochemical determinations, oxidative stress or ACF development analysis, respectively. Immunohistochemical analyses of the colonic mucosa were performed using antibodies against proliferating cell nuclear antigen (PCNA) in normal-appearing colonic crypt and β-catenin in ACF. There was no ACF development in the colon from groups treated with A. crassiflora Mart. pulp. Also, the biochemical and oxidative stress analysis, PCNA labeling and ACF development (number, multiplicity or cellular localization of β-catenin) were unchanged as a result of marolo pulp intake. Thus, the present results suggest that A. crassiflora Mart. pulp intake did not exert any protective effect in the colon carcinogenesis induced by DMH in rats.en
dc.description.affiliationUniversidade Federal de Alfenas/UNIFAL Gabriel Monteiro da Silva, Alfenas - MG
dc.description.affiliationUniversidade Federal de Alfenas/UNIFAL Instituto de Ciências Exatas, Alfenas - MG
dc.description.affiliationUniversidade Estadual Paulista 'Júlio de Mesquita Filho'/UNESP Instituto de Biociências de Botucatu, Botucatu - SP
dc.description.affiliationUniversidade Federal de Alfenas/UNIFAL, Alfenas - MG
dc.description.affiliationUnespUniversidade Estadual Paulista 'Júlio de Mesquita Filho'/UNESP Instituto de Biociências de Botucatu, Botucatu - SP
dc.format.extent343-349
dc.identifierhttp://dx.doi.org/10.1590/S1413-70542013000400008
dc.identifier.citationCiencia e Agrotecnologia, v. 37, n. 4, p. 343-349, 2013.
dc.identifier.doi10.1590/S1413-70542013000400008
dc.identifier.file2-s2.0-84883351310.pdf
dc.identifier.issn1413-7054
dc.identifier.issn1981-1829
dc.identifier.lattes3278528112652257
dc.identifier.scieloS1413-70542013000400008
dc.identifier.scopus2-s2.0-84883351310
dc.identifier.urihttp://hdl.handle.net/11449/75850
dc.identifier.wosWOS:000323723700008
dc.language.isoeng
dc.language.isopor
dc.relation.ispartofCiência e Agrotecnologia
dc.relation.ispartofjcr0.672
dc.relation.ispartofsjr0,383
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAberrant crypt foci
dc.subjectBrazilian savannah
dc.subjectDimethylhydrazine
dc.subjectImmunohistochemistry
dc.subjectOxidative stress
dc.titleEfeitos da polpa do fruto de annona crassiflora mart., nos parâmetros bioquímicos e na carcinogênese de colon de ratospt
dc.title.alternativeAnnona crassiflora mart. Fruit pulp effects on biochemical parameters and rat colon carcinogenesisen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/cagro/iaboutj.htm
unesp.author.lattes3278528112652257
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

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