Efficacy and safety of blood transfusion in obstetric patients: Systematic review of the literature

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dc.contributor.authorMódolo, Celso [UNESP]
dc.contributor.authorAgarwal, Arnav
dc.contributor.authorPiva, Mariana Floriano Luiza [UNESP]
dc.contributor.authorBotan, Andresa Graciutti [UNESP]
dc.contributor.authorCamargo, Samira Esteves Afonso [UNESP]
dc.contributor.authorGawish, Nermeen
dc.contributor.authorMódolo, Norma Sueli Pinheiro [UNESP]
dc.contributor.authorEl Dib, Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionMcMaster University
dc.contributor.institutionUniversity of Toronto
dc.contributor.institutionTanta Chest Hospital
dc.date.accessioned2018-12-11T17:14:26Z
dc.date.available2018-12-11T17:14:26Z
dc.date.issued2017-01-01
dc.description.abstractObjectives: To evaluate the efficacy of blood transfusion compared to no intervention in obstetric patients. Material and methods: A systematic review was performed with Cochrane Database of Clinical Trials, PubMed, EMBASE and LILACS databases searched as of September, 2016. Two authors independently selected relevant clinical trials, assessed their methodological quality and extracted data, using the GRADE approach. Results: Five studies within a total of 6,297 met the inclusion criteria, with women generally aged 20-40 years. Three included studies allocated women to receive blood transfusion or no intervention. Two other studies allocated women with either restricted or full blood supplies. The major issue regarding risk of bias was the extent of concealment of randomization and blinding. There was no statistically significant difference between blood transfusion versus no transfusion or restricted blood supply on mortality (relative risk 0.82 [95% confidential interval 0.32 to 2.09], p = 0.68; two studies; I2 = not applicable). Conclusions: Very low-quality evidence suggests no significant difference between blood transfusion and no intervention in obstetric patients, underlining the need for more robust clinical trials evaluating this area.en
dc.description.affiliationDepartment of Anaesthesiology Botucatu Medical School Unesp - Univ Estadual Paulista
dc.description.affiliationDepartment of Health Research Methods Evidence and Impact McMaster University
dc.description.affiliationSchool of Medicine University of Toronto
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology Unesp - Univ Estadual Paulista
dc.description.affiliationDepartment of Pharmacy Tanta Chest Hospital
dc.description.affiliationInstitute of Urology McMaster University
dc.description.affiliationUnespDepartment of Anaesthesiology Botucatu Medical School Unesp - Univ Estadual Paulista
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology Unesp - Univ Estadual Paulista
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent446-452
dc.identifierhttp://dx.doi.org/10.5603/GP.a2017.0082
dc.identifier.citationGinekologia Polska, v. 88, n. 8, p. 446-452, 2017.
dc.identifier.doi10.5603/GP.a2017.0082
dc.identifier.issn2543-6767
dc.identifier.issn0017-0011
dc.identifier.scopus2-s2.0-85028606028
dc.identifier.urihttp://hdl.handle.net/11449/175115
dc.language.isoeng
dc.relation.ispartofGinekologia Polska
dc.relation.ispartofsjr0,268
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBlood transfusion
dc.subjectObstetric labor
dc.subjectRandomized controlled clinical trials
dc.subjectSystematic review
dc.titleEfficacy and safety of blood transfusion in obstetric patients: Systematic review of the literatureen
dc.typeArtigo

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