False positivity of gamma-glutamyl transpeptidase measurement in urine

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dc.contributor.authorCrivellenti, Leandro Zuccolotto [UNESP]
dc.contributor.authorMesa, Javier Sousa [UNESP]
dc.contributor.authorWilkes Burton Meirelles, Adriana Erica [UNESP]
dc.contributor.authorCrivellenti, Sofia Borin [UNESP]
dc.contributor.authorMireya, Edna Gomes [UNESP]
dc.contributor.authorCanola, Julio Carlos [UNESP]
dc.contributor.authorHatayde, Mario Roberto [UNESP]
dc.contributor.authorSantana, Aureo Evangelista [UNESP]
dc.contributor.authorDantas, Marcio
dc.contributor.authorBarros Silva, Gyl Eanes
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-12-03T13:10:45Z
dc.date.available2014-12-03T13:10:45Z
dc.date.issued2014-05-01
dc.description.abstractAlthough enzymuria tends to be associated to renal injury, there are no studies that have evaluated the presence of the enzyme gamma-glutamyl transpeptidase (GGT) spectrophotometry in the urine using a non-nephrotoxic agent (Nerium oleander) in order to evaluate the possibility of false positive results. The urinary GGT/urinary creatinine concentration ratio (uGGT/uCr) of 10 healthy dogs was calculated and posteriorly confronted with data from clinical evaluation, hematological and serum biochemical profiles, creatinine clearance (CrC), urinalysis, urine protein/creatinine ratio (UPC), electrocardiogram, systemic blood pressure (SBP) and light and electron microscopy. The results for kidney histology, SBP, UPC and CrC were not significantly different in any of the time-points analyzed. However, uGGT/uCr was significantly higher when measured 4 hours and 24 hours after administration of N. oleander. The measurement of the urinary GGT enzyme, as performed in many studies, yielded false positive results in dogs poisoned by a non-nephrotoxic agent.en
dc.description.affiliationSao Paulo State Univ UNESP, Dept Vet Clin & Surg, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationUniv Estado Sao Paulo USP, Fac Med Ribeirao Preto, Dept Renal Pathol, Sao Paulo, Brazil
dc.description.affiliationUniv Estado Sao Paulo USP, Fac Med Ribeirao Preto, Dept Internal Med, Div Nephrol, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Dept Vet Clin & Surg, BR-14884900 Jaboticabal, SP, Brazil
dc.format.extent581-584
dc.identifierhttp://dx.doi.org/10.3109/0886022X.2014.880325
dc.identifier.citationRenal Failure. London: Informa Healthcare, v. 36, n. 4, p. 581-584, 2014.
dc.identifier.doi10.3109/0886022X.2014.880325
dc.identifier.issn0886-022X
dc.identifier.lattes3144173608741010
dc.identifier.lattes8905659987198068
dc.identifier.urihttp://hdl.handle.net/11449/112482
dc.identifier.wosWOS:000334936400016
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofRenal Failure
dc.relation.ispartofjcr1.440
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectEnzymuriaen
dc.subjectGGT/urinary creatinineen
dc.subjectKidneyen
dc.subjectnephrotoxicityen
dc.titleFalse positivity of gamma-glutamyl transpeptidase measurement in urineen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dcterms.rightsHolderInforma Healthcare
unesp.author.lattes3144173608741010
unesp.author.lattes8905659987198068[8]
unesp.author.orcid0000-0001-8515-6423[9]
unesp.author.orcid0000-0003-4539-1802[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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