A Single Intraoperative Sub-Tenon's Capsule Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System for Cataract Surgery

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dc.contributor.authorPaganelli, Fernando
dc.contributor.authorCardillo, Jose A.
dc.contributor.authorMelo, Luiz A. S.
dc.contributor.authorLucena, David R.
dc.contributor.authorSilva, Arnobio A. [UNESP]
dc.contributor.authorOliveira, Anselmo Gomes de [UNESP]
dc.contributor.authorHoefling-Lima, Ana L.
dc.contributor.authorNguyen, Quan Dong
dc.contributor.authorKuppermann, Baruch D.
dc.contributor.authorBelfort, Rubens
dc.contributor.institutionHosp Olhos Araraquara
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Araraquara
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionJohns Hopkins Univ
dc.contributor.institutionUniv Calif Irvine
dc.date.accessioned2014-05-20T13:24:43Z
dc.date.available2014-05-20T13:24:43Z
dc.date.issued2009-07-01
dc.description.abstractPURPOSE. To compare intraoperative injection of triamcinolone and ciprofloxacin in a controlled-release system (DuoCat) with prednisolone and ciprofloxacin eye drops after cataract surgery.METHODS. In this randomized, double-masked, controlled trial, a total of 135 patients undergoing cataract surgery were randomly allocated to two groups: 67 patients treated after surgery with prednisolone 1% and ciprofloxacin 3% eye drops four times daily (week 1), three times daily (week 2), twice daily (week 3), and once daily (week 4) and 0.3% ciprofloxacin drops four times daily (weeks 1 and 2), and 68 patients treated at the end of surgery with a sub-Tenon's injection of 25 mg triamcinolone and 2 mg ciprofloxacin in biodegradable microspheres. The patients were examined on postoperative days 1, 3, 7, 14, and 28. The main outcome measures were postoperative anterior chamber cell and flare, intraocular pressure (IOP), lack of anti-inflammatory response, and presence of infection.RESULTS. No significant differences were observed between the groups in anterior chamber cell (P > 0.14) and flare (P > 0.02) at any postoperative visits. The mean (99% confidence interval) differences in IOP between the prednisolone and triamcinolone groups on days 1, 3, 7, 14, and 28 were -0.4 mm Hg (-2.1 to 1.3), 0.0 mm Hg (-1.4 to 1.3), 0.0 mm Hg (-1.1 to 1.1), -0.2 mm Hg (-1.1 to 0.8), and -0.1 mm Hg (-1.1 to 0.9), respectively. No patient had a postoperative infection.CONCLUSIONS. One injection of DuoCat had a therapeutic response and ocular tolerance that were equivalent to conventional eye drops in controlling inflammation after cataract surgery. (Clinical-Trials. gov number, NCT00431028.) (Invest Ophthalmol Vis Sci. 2009; 50: 3041-3047) DOI: 10.1167/iovs.08-2920en
dc.description.affiliationHosp Olhos Araraquara, BR-14802530 Araraquara SP, Brazil
dc.description.affiliationUniv Fed São Paulo, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationUniv Araraquara, Dept Ophthalmol, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Sch Pharmaceut Sci, São Paulo, Brazil
dc.description.affiliationJohns Hopkins Univ, Wilmer Eye Inst, Retina Div, Baltimore, MD 21218 USA
dc.description.affiliationUniv Calif Irvine, Dept Ophthalmol, Irvine, CA USA
dc.description.affiliationUnespSão Paulo State Univ, Sch Pharmaceut Sci, São Paulo, Brazil
dc.format.extent3041-3047
dc.identifierhttp://dx.doi.org/10.1167/iovs.08-2920
dc.identifier.citationInvestigative Ophthalmology & Visual Science. Rockville: Assoc Research Vision Ophthalmology Inc, v. 50, n. 7, p. 3041-3047, 2009.
dc.identifier.doi10.1167/iovs.08-2920
dc.identifier.issn0146-0404
dc.identifier.lattes9114495952533044
dc.identifier.urihttp://hdl.handle.net/11449/7754
dc.identifier.wosWOS:000267292100001
dc.language.isoeng
dc.publisherAssoc Research Vision Ophthalmology Inc
dc.relation.ispartofInvestigative Ophthalmology & Visual Science
dc.relation.ispartofjcr3.388
dc.relation.ispartofsjr2,058
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleA Single Intraoperative Sub-Tenon's Capsule Injection of Triamcinolone and Ciprofloxacin in a Controlled-Release System for Cataract Surgeryen
dc.typeArtigo
dcterms.licensehttp://www.iovs.org/site/misc/terms.xhtml
dcterms.rightsHolderAssoc Research Vision Ophthalmology Inc
unesp.author.lattes9114495952533044[6]
unesp.author.orcid0000-0002-0107-9940[6]
unesp.author.orcid0000-0002-8422-3898[10]
unesp.author.orcid0000-0002-5791-3201[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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