Biocompatibility of glass-ionomer cements using mouse lymphoma cells in vitro

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dc.contributor.authorRibeiro, D. A.
dc.contributor.authorMarques, Mariângela Esther Alencar [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:37:02Z
dc.date.available2014-05-20T13:37:02Z
dc.date.issued2006-12-01
dc.description.abstractGlass-ionomer cements are widely used in dentistry as restorative materials and adhesives for composite restorations. A number of genotoxicity studies have been conducted using these materials with results conflicting so far. Thus, the approach was aimed to look at the genotoxic and cytotoxic potential of three different glass-ionomer cements available commercially (Ketac Cem, Ketac Molar and Vitrebond) by the single cell gel (comet) assay and trypan blue exclusion test, respectively. For this, such materials were exposed to mouse lymphoma cells in vitro for 1 h at 37 degrees C. Data were assessed by Kruskall-Wallis non-parametric test. The results showed that all powders assayed did not show genotoxic effects. on the other hand, the liquid from Vitrebond at 0.1% dilution caused an increase of DNA injury. Significant statistically differences (P < 0.05) in cytotoxicity provoked by all powders tested were observed for exposure at 1000 mu g mL(-1) concentration and 100 mu g mL(-1) for Ketac Molar. With respect to liquids of glass-ionomer cements evaluated, the major toxic effect on cell viability was produced at 1%, beginning at the dilution of 0.5% for Vitrebond. Taken together, these results support the notion that some components of glass-ionomer cements show both genotoxic and cytotoxic effects in higher concentrations.en
dc.description.affiliationUniv Fed São Paulo, Dept Hlth Sci, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Botucatu Med Sch, TOXICAN, Ctr Genotoxins & Carcinogens Evaluat,Dept Pathol, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Botucatu Med Sch, TOXICAN, Ctr Genotoxins & Carcinogens Evaluat,Dept Pathol, Botucatu, SP, Brazil
dc.format.extent912-917
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2842.2006.01658.x
dc.identifier.citationJournal of Oral Rehabilitation. Oxford: Blackwell Publishing, v. 33, n. 12, p. 912-917, 2006.
dc.identifier.doi10.1111/j.1365-2842.2006.01658.x
dc.identifier.issn0305-182X
dc.identifier.lattes5051118752980903
dc.identifier.lattes7528116925519142
dc.identifier.urihttp://hdl.handle.net/11449/12773
dc.identifier.wosWOS:000242235400006
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofJournal of Oral Rehabilitation
dc.relation.ispartofjcr2.051
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcytotoxicitypt
dc.subjectgenotoxicitypt
dc.subjectglass-ionomer cementspt
dc.subjectmouse lymphoma cellspt
dc.titleBiocompatibility of glass-ionomer cements using mouse lymphoma cells in vitroen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing
unesp.author.lattes5051118752980903
unesp.author.lattes7528116925519142
unesp.author.orcid0000-0001-9323-3134[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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