Activity of 3′-hydroxychalcone against Cryptococcus gattii and toxicity, and efficacy in alternative animal models

Página do item simplificado
dc.contributor.authorPalanco, Ana Cerrejón [UNESP]
dc.contributor.authorLacorte Singulani, Junya De [UNESP]
dc.contributor.authorCosta-Orlandi, Caroline Barcelos [UNESP]
dc.contributor.authorGullo, Fernanda Patrícia [UNESP]
dc.contributor.authorStrohmayer Lourencetti, Natália Manuela [UNESP]
dc.contributor.authorGomes, Paulo César [UNESP]
dc.contributor.authorAyusso, Gabriela Miranda [UNESP]
dc.contributor.authorDutra, Luiz Antônio [UNESP]
dc.contributor.authorSilva Bolzani, Vanderlan Da [UNESP]
dc.contributor.authorRegasini, Luis Octávio [UNESP]
dc.contributor.authorSoares Mendes-Giannini, Maria José [UNESP]
dc.contributor.authorFusco-Almeida, Ana Marisa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:34:23Z
dc.date.available2018-12-11T17:34:23Z
dc.date.issued2017-10-01
dc.description.abstractAim: This work aimed to evaluate the activity of 3′-hydroxychalcone against Cryptococcus gattii in planktonic and biofilm forms and their toxicity using alternative animal models. Materials & methods: Minimum inhibitory concentration and minimum fungicide concentration were determined. Biofilm formation and the susceptibility tests were performed by the 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-5-[carbonyl(phenylamino)]-2H-tetrazolium hydroxide assay. Toxicity and efficacy were checked in Danio rerio and Galleria mellonella models. Results: The compound 3′-hydroxychalcone showed fungicidal activity against C. gattii in both planktonic and biofilm forms. The toxicity in zebrafish embryos revealed a low lethal concentration. In G. mellonella, the compound did not show antifungal activity and larvae toxicity. Conclusion: Because of the activity of 3′-hydroxychalcone against C. gattii in vitro, molecular modifications should be made to improve efficacy and to reduce toxicity in vivo. </inline-graphic.en
dc.description.affiliationSchool of Pharmaceutical Sciences UNESP-São Paulo State University
dc.description.affiliationInstitute of Biosciences Letters and Exact Sciences UNESP-São José Do Rio Preto
dc.description.affiliationInstitute of Chemistry UNESP-Araraquara
dc.description.affiliationUnespSchool of Pharmaceutical Sciences UNESP-São Paulo State University
dc.description.affiliationUnespInstitute of Biosciences Letters and Exact Sciences UNESP-São José Do Rio Preto
dc.description.affiliationUnespInstitute of Chemistry UNESP-Araraquara
dc.format.extent1123-1134
dc.identifierhttp://dx.doi.org/10.2217/fmb-2017-0062
dc.identifier.citationFuture Microbiology, v. 12, n. 13, p. 1123-1134, 2017.
dc.identifier.doi10.2217/fmb-2017-0062
dc.identifier.issn1746-0921
dc.identifier.issn1746-0913
dc.identifier.lattes3637285622123132
dc.identifier.lattes0992736452764550
dc.identifier.orcid0000-0003-2440-8097
dc.identifier.scopus2-s2.0-85030651400
dc.identifier.urihttp://hdl.handle.net/11449/179253
dc.language.isoeng
dc.relation.ispartofFuture Microbiology
dc.relation.ispartofsjr1,270
dc.relation.ispartofsjr1,270
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectantifungal
dc.subjectbiofilm
dc.subjectchalcone
dc.subjectcryptococcosis
dc.subjectGalleria mellonella
dc.subjectzebrafish
dc.titleActivity of 3′-hydroxychalcone against Cryptococcus gattii and toxicity, and efficacy in alternative animal modelsen
dc.typeArtigo
unesp.author.lattes3637285622123132[6]
unesp.author.lattes0992736452764550
unesp.author.lattes3716273524139678[12]
unesp.author.orcid0000-0003-2440-8097[6]
unesp.author.orcid0000-0002-2115-8988[12]

Arquivos

Coleções

Artigos - Análises Clínicas - FCFAR