Lower sperm quality and testicular and epididymal structural impairment in adult rats exposed to rosuvastatin during prepuberty

Página do item simplificado
dc.contributor.authorLeite, Gabriel Adan Araújo [UNESP]
dc.contributor.authorSanabria, Marciana [UNESP]
dc.contributor.authorCavariani, Marilia Martins [UNESP]
dc.contributor.authorAnselmo-Franci, Janete Aparecida
dc.contributor.authorPinheiro, Patrícia Fernanda Felipe [UNESP]
dc.contributor.authorDomeniconi, Raquel Fantin [UNESP]
dc.contributor.authorKempinas, Wilma De Grava [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:35:58Z
dc.date.available2018-12-11T17:35:58Z
dc.date.issued2018-06-01
dc.description.abstractThe increase of obesity, bad eating habits and the lack of physical exercises are highly related to dyslipidemias. Rosuvastatin is a lipid-lowering drug and has been indicated to prevent cardiovascular diseases and to treat dyslipidemias due to its higher efficiency to reduce serum cholesterol concentrations. This study aimed to evaluate the reproductive adverse effects on sexual maturity due to rosuvastatin exposure in juvenile male rats during prepuberty. Three groups were randomly formed with newly weaned rats: control, whose rats received saline solution 0.9% and rosuvastatin at doses of 3 or 10 mg kg–1 day–1, administered orally by gavage, from postnatal day 21 until preputial separation (average of 45 days for controls and 49 days for statin-treated animals), indicative of puberty onset. Male rats were maintained until sexual maturity and were killed on postnatal day 110. In the rosuvastatin-treated groups, the results showed diminished follicle-stimulating hormone, luteinizing hormone and testosterone concentrations, increased estradiol and prolactin concentrations, histopathologic alterations on testis and epididymis and decreased sperm quality. Moreover, statin-exposed groups showed decreased expression of androgen receptor on testis and epididymis and lower expression of aquaporin-9 on epididymal epithelium. In conclusion, administration of rosuvastatin to prepubertal male rats provoked long-term hormonal deregulation and impaired reproduction at adulthood.en
dc.description.affiliationDepartment of Morphology São Paulo State University (UNESP) Institute of Biosciences
dc.description.affiliationDepartment of Morphology Stomatology and Physiology School of Dentistry USP – University of São Paulo, Ribeirão Preto
dc.description.affiliationDepartment of Anatomy São Paulo State University (UNESP) Institute of Biosciences
dc.description.affiliationUnespDepartment of Morphology São Paulo State University (UNESP) Institute of Biosciences
dc.description.affiliationUnespDepartment of Anatomy São Paulo State University (UNESP) Institute of Biosciences
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 011/15065-5
dc.format.extent914-929
dc.identifierhttp://dx.doi.org/10.1002/jat.3599
dc.identifier.citationJournal of Applied Toxicology, v. 38, n. 6, p. 914-929, 2018.
dc.identifier.doi10.1002/jat.3599
dc.identifier.issn1099-1263
dc.identifier.issn0260-437X
dc.identifier.lattes5760560970751598
dc.identifier.lattes5481756528299469
dc.identifier.orcid0000-0003-1452-5708
dc.identifier.orcid0000-0003-2938-010X
dc.identifier.scopus2-s2.0-85042163393
dc.identifier.urihttp://hdl.handle.net/11449/179594
dc.language.isoeng
dc.relation.ispartofJournal of Applied Toxicology
dc.relation.ispartofsjr0,958
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectandrogen
dc.subjectepididymis
dc.subjectmale reproduction
dc.subjectRosuvastatin
dc.subjecttestis
dc.subjecttoxicology
dc.titleLower sperm quality and testicular and epididymal structural impairment in adult rats exposed to rosuvastatin during prepubertyen
dc.typeArtigo
unesp.author.lattes5760560970751598[5]
unesp.author.lattes5481756528299469[6]
unesp.author.orcid0000-0002-9437-6310[1]
unesp.author.orcid0000-0003-1452-5708[5]
unesp.author.orcid0000-0003-2938-010X[6]

Arquivos

Coleções

Artigos - Anatomia - IBB
Artigos - Morfologia - IBB