Metronidazole release using natural rubber latex as matrix

Página do item simplificado
dc.contributor.authorHerculano, Rondinelli Donizetti [UNESP]
dc.contributor.authorGuimarães, Sérgio Augusto Catanzaro
dc.contributor.authorBelmonte, Gustavo Campos
dc.contributor.authorDuarte, Marco Antonio Hungaro
dc.contributor.authorOliveira Júnior, Osvaldo Novais de
dc.contributor.authorKinoshita, Angela
dc.contributor.authorGraeff, Carlos Frederico de Oliveira [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade do Sagrado Coração
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:26:11Z
dc.date.available2014-05-20T13:26:11Z
dc.date.issued2010-03-01
dc.description.abstractNatural Rubber Latex (NRL) can be used successfully in controlled release drug delivery due to their excellent matrix forming properties. Recently, NRL has shown to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. A dermatological delivery system comprising a topically acceptable, inert support impregnated with a metronidazole (MET) solution was developed. MET 2-(2- methyl- 5-nitro- 1H- imidazol- 1-yl) ethanol, has been widely used for the treatment of protozoa and anaerobic bacterial infections. MET is a nitroimidazole anti-infective medication used mainly in the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. In a previous study, we have tested NRL as an occlusive membrane for GBR with promising results. One possible way to decrease the inflammatory process, it was incorporated the MET in NRL. MET was incorporated into the NRL, by mixing it in solution for in vitro protein delivery experiments. The solutions of latex and MET were polymerized at different temperatures, from -100 to 40 °C, in order to control the membrane morphology. SEM microscopy analysis showed that the number, size and distribution of pores in NRL membranes varied depending on polymerization temperature, as well as its overall morphology. Results demonstrated that the best drug-delivery system was the membrane polymerized at -100 °C, which does release 77,1% of its MET content for up 310 hours.en
dc.description.affiliationUSP Instituto de Física de São Carlos Departamento de Física e Ciências dos Materiais
dc.description.affiliationUniversidade do Sagrado Coração
dc.description.affiliationUNESP Faculdade de Ciências Departamento de Física
dc.description.affiliationUnespUNESP Faculdade de Ciências Departamento de Física
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent57-61
dc.identifierhttp://dx.doi.org/10.1590/S1516-14392010000100013
dc.identifier.citationMaterials Research. ABM, ABC, ABPol, v. 13, n. 1, p. 57-61, 2010.
dc.identifier.doi10.1590/S1516-14392010000100013
dc.identifier.fileS1516-14392010000100013.pdf
dc.identifier.issn1516-1439
dc.identifier.orcid0000-0003-0162-8273
dc.identifier.scieloS1516-14392010000100013
dc.identifier.urihttp://hdl.handle.net/11449/8405
dc.identifier.wosWOS:000276894200013
dc.language.isoeng
dc.publisherABM, ABC, ABPol
dc.relation.ispartofMaterials Research
dc.relation.ispartofjcr1.103
dc.relation.ispartofsjr0,398
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectbiomaterialsen
dc.subjectlatex membraneen
dc.subjectmetronidazoleen
dc.subjectdrug delivery systemen
dc.titleMetronidazole release using natural rubber latex as matrixen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/mr/paboutj.htm
unesp.author.lattes5268607684223281[7]
unesp.author.orcid0000-0003-0162-8273[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências, Baurupt
unesp.departmentFísica - FCpt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
S1516-14392010000100013.pdf
Tamanho:
1.42 MB
Formato:
Adobe Portable Document Format
Baixar
Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Bauru - FC - Faculdade de Ciências