Efectos de la administración de betabloqueante en la remodelación ventricular inducida por el tabaquismo en ratas

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dc.contributor.authorDuarte, Daniella R. [UNESP]
dc.contributor.authorOliveira, Lucienne C. [UNESP]
dc.contributor.authorMinicucci, Marcos Ferreira [UNESP]
dc.contributor.authorGaiolla, Paula Schmidt Azevedo [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorCampana, Álvaro O. [UNESP]
dc.contributor.authorPaiva, Sergio Alberto Rupp de [UNESP]
dc.contributor.authorZornoff, Leonardo Antonio Mamede [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:54Z
dc.date.available2014-05-27T11:23:54Z
dc.date.issued2009-06-01
dc.description.abstractBackground: The role of the adrenergic system on ventricular remodeling induced by cigarette smoking is unknown. Objective: To investigate the influence of propranolol on ventricular remodeling induced by exposure to tobacco smoke. Methods: Rats were divided into three groups: 1) C, n=10 - control group; 2) F, n=10 - animals exposed to tobacco smoke; 3) BB, n=10 - animals receiving propranolol and exposed to tobacco smoke (40 mg/kg/day). After 2 months, the animals underwent echocardiographic and morphometric analyses. One-way ANOVA (mean ± standard deviation) or the Kruskal-Wallis test (median and interquartile interval) was used. Results: Group BB showed a lower heart rate than group F (C = 358 ± 74 bpm, F = 374 ± 53 bpm, BB = 297± 30; P = 0.02). Group F showed greater end-diastolic diameters (C = 18.6 ± 3.4 mm/kg, F = 22.8 ± 1.8 mm/kg, BB = 21.7 ± 1.8 mm/kg; P = 0.003) and left ventricular (LV) end-systolic diameters (C = 8.6 ± 2.1 mm/kg, F = 11.3 ± 1.3 mm/kg, BB = 9.9 ± 1.2 mm/kg; P = 0.004), adjusted for body weight (BW) and a tendency towards a lower ejection fraction (C = 0.90 ± 0.03, F = 0.87 ± 0.03, BB =0.90 ± 0.02; P = 0.07) than group C. Group BB showed a tendency towards a lower LV/BW ratio than group F (C = 1.94 (1.87 - 1.97), F = 2.03 (1.9-2.1) mg/g, BB = 1.89 (1.86-1.94); P = 0.09). Conclusion: Administration of propranolol attenuated some of the variables of ventricular remodeling induced by the exposure to tobacco smoke in rats.en
dc.description.affiliationFaculdade de Medicina de Botucatu Departamento de Clínica Médica, Rubião Jr, 18618-000, Botucatu, SP
dc.description.affiliationUnespFaculdade de Medicina de Botucatu Departamento de Clínica Médica, Rubião Jr, 18618-000, Botucatu, SP
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X2009000600011
dc.identifier.citationArquivos Brasileiros de Cardiologia, v. 92, n. 6, 2009.
dc.identifier.doi10.1590/S0066-782X2009000600011
dc.identifier.file2-s2.0-68049098946.pdf
dc.identifier.issn0066-782X
dc.identifier.issn1678-4170
dc.identifier.lattes6990977122340795
dc.identifier.lattes6309835137998766
dc.identifier.lattes5016839015394547
dc.identifier.lattes1213140801402647
dc.identifier.lattes7438704034471673
dc.identifier.orcid0000-0002-5843-6232
dc.identifier.scieloS0066-782X2009000600011
dc.identifier.scopus2-s2.0-68049098946
dc.identifier.urihttp://hdl.handle.net/11449/71015
dc.language.isopor
dc.language.isospa
dc.language.isoeng
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.relation.ispartofjcr1.318
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAdrenergic beta-antagonists/administration & dosage
dc.subjectRats
dc.subjectSmoking
dc.subjectVentricular remodeling
dc.subjectpropranolol
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectbody weight
dc.subjectcigarette smoking
dc.subjectcontrolled study
dc.subjectechocardiography
dc.subjectheart ejection fraction
dc.subjectheart rate
dc.subjectheart ventricle remodeling
dc.subjectmale
dc.subjectmorphometrics
dc.subjectnonhuman
dc.subjectrat
dc.subjectAdrenergic beta-Antagonists
dc.subjectAnimals
dc.subjectInhalation Exposure
dc.subjectMale
dc.subjectModels, Animal
dc.subjectPropranolol
dc.subjectRats, Wistar
dc.subjectTobacco Smoke Pollution
dc.subjectVentricular Dysfunction, Left
dc.subjectVentricular Remodeling
dc.titleEfectos de la administración de betabloqueante en la remodelación ventricular inducida por el tabaquismo en rataspt
dc.title.alternativeEffects of the administration of beta-blockers on ventricular remodeling induced by cigarette smoking in ratsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/abc/iaboutj.htm
unesp.author.lattes5016839015394547
unesp.author.lattes6990977122340795
unesp.author.lattes6309835137998766
unesp.author.lattes1213140801402647[4]
unesp.author.lattes7438704034471673
unesp.author.orcid0000-0002-5843-6232[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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