Chronic ethanol intake leads to structural and molecular alterations in the rat endometrium

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dc.contributor.authorMartinez, Marcelo
dc.contributor.authorMilton, Flora A.
dc.contributor.authorPinheiro, Patricia Fernanda F. [UNESP]
dc.contributor.authorAlmeida-Francia, Camila C.D. [UNESP]
dc.contributor.authorCagnon-Quitete, Valeria H.A.
dc.contributor.authorTirapelli, Luiz F.
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorChuffa, Luiz Gustavo A. [UNESP]
dc.contributor.authorMartinez, Francisco Eduardo [UNESP]
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:27:47Z
dc.date.available2018-12-11T17:27:47Z
dc.date.issued2016-05-01
dc.description.abstractWe described the effects of low- and high-dose ethanol intake on the structure and apoptosis signaling of the uterine endometrium of UChA and UChB rats (animals with voluntary ethanol consumption). Thirty adult female rats, 90 days old, were divided into three groups (n = 10/group): UChA rats fed with 10% (v/v) ethanol ad libitum (free choice for water or ethanol) drinking < 1.9 g/kg/day; UChB rats fed with 10% (v/v) ethanol ad libitum (free choice for water or ethanol) drinking from 2 to 5 g/kg/day; control rats without ethanol (only water). After 120 days of treatment, rats displaying estrus were euthanized. Uterine epithelial cells of the UCh rats showed dilated cisterns of the rough endoplasmic reticulum, presence of lipid droplets, altered nuclear chromatin, and disrupted mitochondria. The UCh rats exhibited intense atrophied epithelial cells with smaller areas and perimeters of cytoplasm and nuclei. The endometrium of UChA rats showed higher levels of caspase-3 while Xiap and Bcl2 varied from moderate to weak. Both UChA and UChB rats exhibited a stronger immunoreaction to Ki-67 and IGFR-1 on epithelial and stromal cells. Chronic ethanol intake leads to structural and molecular alterations in the uterine endometrium of UCh rats, regardless of low- or high-dose consumption, promoting reproductive disorders.en
dc.description.affiliationDepartment of Morphology and Pathology UFSCar
dc.description.affiliationDepartment of Anatomy UNESP
dc.description.affiliationDepartment of Biostatistics UNESP
dc.description.affiliationDepartment of Anatomy Cellular Biology Physiology and Biophysics UNICAMP
dc.description.affiliationDepartment of Surgery and Anatomy USP
dc.description.affiliationUnespDepartment of Anatomy UNESP
dc.description.affiliationUnespDepartment of Biostatistics UNESP
dc.format.extent55-61
dc.identifierhttp://dx.doi.org/10.1016/j.alcohol.2016.02.002
dc.identifier.citationAlcohol, v. 52, p. 55-61.
dc.identifier.doi10.1016/j.alcohol.2016.02.002
dc.identifier.file2-s2.0-84962647663.pdf
dc.identifier.issn1873-6823
dc.identifier.issn0741-8329
dc.identifier.lattes5760560970751598
dc.identifier.orcid0000-0003-1452-5708
dc.identifier.scopus2-s2.0-84962647663
dc.identifier.urihttp://hdl.handle.net/11449/177937
dc.language.isoeng
dc.relation.ispartofAlcohol
dc.relation.ispartofsjr1,153
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectApoptosis
dc.subjectEpithelium
dc.subjectEthanol
dc.subjectTEM
dc.subjectUCh rat
dc.subjectUterus
dc.titleChronic ethanol intake leads to structural and molecular alterations in the rat endometriumen
dc.typeArtigo
unesp.author.lattes5760560970751598[3]
unesp.author.lattes4791367810581192[4]
unesp.author.lattes8727897080522289[7]
unesp.author.orcid0000-0003-1452-5708[3]
unesp.author.orcid0000-0003-0832-6083[4]
unesp.author.orcid0000-0002-7719-9682[7]

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Artigos - Bioestatística - IBB
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