The Effect of Schinus terebinthifolius Raddi (Anacardiaceae) Bark Extract on Histamine-Induced Paw Edema and Ileum Smooth Muscle Contraction

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dc.contributor.authorNunes-Neto, Paulo Alexandre
dc.contributor.authorPeixoto-Sobrinho, Tadeu José Da Silva
dc.contributor.authorDa Silva Júnior, Edilson Dantas
dc.contributor.authorLeopoldina Da Silva, Jamilka
dc.contributor.authorRodrigo Da Silva Oliveira, Alisson
dc.contributor.authorPupo, André Sampaio [UNESP]
dc.contributor.authorAraújo, Alice Valencą
dc.contributor.authorCosta-Silva, Joaõ Henrique Da
dc.contributor.authorWanderley, Almir Goncąlves
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionFederal University of Saõ Paulo
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:34:15Z
dc.date.available2018-12-11T17:34:15Z
dc.date.issued2017-01-01
dc.description.abstractSchinus terebinthifolius Raddi (Anacardiaceae), popularly known as red aroeira, is used in traditional medicine to treat inflammatory, gastric, and respiratory disorders. The aim of this study was to evaluate the antihistaminic activity of S. terebinthifolius (St) bark extract by using in vivo and in vitro experimental models. The effects of St were investigated on contractions induced by histamine, carbachol, and potassium chloride in isolated Guinea pig ileum. St was also studied in response to hind paw edema induced by histamine in rats. Experiments revealed that although St (250, 500, and 1,000 μg/mL) reduced the histamine-induced contractions by 9.1±1.8, 50.2±2.0, and 68.9±2.0%, respectively, it did not inhibit contractions induced by carbachol or KCl. The association of St (250 and 500 μg/mL) with hydroxyzine, an H1-antihistamine (0.125 and 0.250 μM), increased the inhibitory effect to 67.0±3.2 and 85.1±2.1%, respectively. Moreover, St (100, 200, and 400 mg/kg) decreased paw edema from its peak by 33.9, 48.4, and 54.8%, respectively, whereas hydroxyzine (70 mg/kg) inhibited the peak edema by 56.5%. Altogether, the results suggest that the bark extract of S. terebinthifolius has an antihistaminic effect (H1).en
dc.description.affiliationDepartment of Pharmaceutical Sciences Federal University of Pernambuco
dc.description.affiliationDepartment of Pharmacology Federal University of Saõ Paulo
dc.description.affiliationDepartment of Pharmacology Instituto de Biociências UNESP
dc.description.affiliationDepartment of Physical Education and Sport Sciences Federal University of Pernambuco
dc.description.affiliationDepartment of Physiology and Pharmacology Federal University of Pernambuco
dc.description.affiliationUnespDepartment of Pharmacology Instituto de Biociências UNESP
dc.identifierhttp://dx.doi.org/10.1155/2017/1416375
dc.identifier.citationEvidence-based Complementary and Alternative Medicine, v. 2017.
dc.identifier.doi10.1155/2017/1416375
dc.identifier.file2-s2.0-85029811519.pdf
dc.identifier.issn1741-4288
dc.identifier.issn1741-427X
dc.identifier.scopus2-s2.0-85029811519
dc.identifier.urihttp://hdl.handle.net/11449/179215
dc.language.isoeng
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine
dc.relation.ispartofsjr0,683
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleThe Effect of Schinus terebinthifolius Raddi (Anacardiaceae) Bark Extract on Histamine-Induced Paw Edema and Ileum Smooth Muscle Contractionen
dc.typeArtigo
unesp.author.lattes2224433126054725[6]
unesp.author.orcid0000-0003-3526-2206[2]
unesp.author.orcid0000-0002-9794-1418[8]
unesp.author.orcid0000-0001-5193-1153[9]
unesp.author.orcid0000-0001-6627-3448[6]

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