Effect of Helicobacter pylori infection on IL-8, IL-1 and COX-2 expression in patients with chronic gastritis and gastric cancer

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dc.contributor.authorBartchewsky, Waldemar
dc.contributor.authorMartini, Mariana Rocha
dc.contributor.authorMasiero, Mariana
dc.contributor.authorSquassoni, Aline Candido
dc.contributor.authorAlvarez, Marisa Claudia
dc.contributor.authorLadeira, Marcelo Sady [UNESP]
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorTrevisan, Miriam
dc.contributor.authorPedrazzoli, Jose
dc.contributor.authorRibeiro, Marcelo Lima
dc.contributor.institutionUniv Sao Francisco
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionLab MULTIPAT
dc.date.accessioned2014-05-20T13:33:18Z
dc.date.available2014-05-20T13:33:18Z
dc.date.issued2009-01-01
dc.description.abstractObjective. Helicobacter pylori infection is related to gastric cancer development, and chronic inflammation is presumed to be the main cause. The aim of the present study was to evaluate the influence of H. pylori cagA, vacA, iceA, and babA genotypes on COX-2, IL-1, and IL-8 expression. Material and methods. of the 217 patients included in the study, 26 were uninfected, 127 had chronic gastritis and were H. pylori-positive, and 64 had gastric cancer. Bacterial genotypes were evaluated by polymerase chain reaction (PCR), and the expression values were determined by quantitative real-time PCR and immunohistochemistry. Results. An association was found between the infection with cagA, vacA s1m1 strains and gastric cancer development. Regarding the 3' region of the cagA gene, we also found an association between the infection with cagA EPIYA-ABCCC strains and clinical outcome. Higher levels of IL-8, IL-1, and COX-2 were detected in gastric mucosa from infected patients with chronic gastritis, and they were also associated with the infection by cagA, vacA s1m1 strains. The IL-8 and IL-1 levels decrease significantly from chronic gastritis to gastric cancer, while the relative expression remained unaltered when COX-2 expression was analyzed among patients with gastritis and cancer. Conclusions. Since inflammatory response to H. pylori infection plays an important role in cellular proliferation and gastric mucosal damage, the up-regulation of IL-1, IL-8, and COX-2 in patients with chronic gastritis has an important clinical implication in gastric carcinogenesis.en
dc.description.affiliationUniv Sao Francisco, Unidade Integrada Farmacol & Gastroenterol, BR-12900000 Braganca Paulista, SP, Brazil
dc.description.affiliationUNESP, Dpto Clin Med, Botucatu, SP, Brazil
dc.description.affiliationUNESP, Dpto Patol, Botucatu, SP, Brazil
dc.description.affiliationLab MULTIPAT, Campinas, SP, Brazil
dc.description.affiliationUnespUNESP, Dpto Clin Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dpto Patol, Botucatu, SP, Brazil
dc.format.extent153-161
dc.identifierhttp://dx.doi.org/10.1080/00365520802530853
dc.identifier.citationScandinavian Journal of Gastroenterology. Oslo: Taylor & Francis As, v. 44, n. 2, p. 153-161, 2009.
dc.identifier.doi10.1080/00365520802530853
dc.identifier.issn0036-5521
dc.identifier.lattes5051118752980903
dc.identifier.urihttp://hdl.handle.net/11449/11390
dc.identifier.wosWOS:000262643800004
dc.language.isoeng
dc.publisherTaylor & Francis As
dc.relation.ispartofScandinavian Journal of Gastroenterology
dc.relation.ispartofjcr2.629
dc.relation.ispartofsjr1,226
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCOX-2en
dc.subjectHen
dc.subjectpylorien
dc.subjectIL-1en
dc.subjectIL-8en
dc.titleEffect of Helicobacter pylori infection on IL-8, IL-1 and COX-2 expression in patients with chronic gastritis and gastric canceren
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/page/TermsAndConditions
dcterms.rightsHolderTaylor & Francis As
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0003-4529-7832[10]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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