Influence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesis

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dc.contributor.authorDa Silva, Aleksandro S.
dc.contributor.authorMunhoz, Thiago D. [UNESP]
dc.contributor.authorFaria, Joice L.M.
dc.contributor.authorVargas-Hérnandez, Giovanni [UNESP]
dc.contributor.authorMachado, Rosangela Z. [UNESP]
dc.contributor.authorLuz, Nathalia C.
dc.contributor.authorMoritz, Cesar E.J.
dc.contributor.authorCasali, Emerson A.
dc.contributor.authorBottari, Nathieli B.
dc.contributor.authorStefani, Lenita M.
dc.contributor.authorTinucci-Costa, Mirela [UNESP]
dc.contributor.institutionUniversidade do Estado de Santa Catarina (UDESC)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Federal Catarinense
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.date.accessioned2014-05-27T11:30:52Z
dc.date.available2014-05-27T11:30:52Z
dc.date.issued2013-10-25
dc.description.abstractThe aim of this study was to evaluate adenosine deaminase activity and purines levels in serum of dogs experimentally infected by Ehrlichia canis. Banked serum samples of dogs divided into two groups with five animals each: healthy animals and animals infected by E. canis. The concentration of purines (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenosine, inosine, hypoxanthine, xanthine and uric acid), and adenosine deaminase (E-ADA) activity in sera were evaluated. Samples were collected on days 12 and 30 post-infection (PI). The E-ADA activity showed a significant reduction on day 12 PI, and increased on day 30 PI in dogs infected with E. canis. On day 12, an increase in seric concentration of ATP, ADP and adenosine was verified, and different levels of hypoxanthine, xanthine and uric acid had a drastic reduction in infected compared healthy dogs (P< 0.05). However, on day 30 PI, the levels of seric ADP and AMP decreased, unlike the concentration of xanthine and uric acid that increased significantly in infected dogs (P< 0.05). Therefore, the activity of E-ADA and purine levels are altered in experimental canine ehrlichiosis, probably with the purpose of modulating the pathogenesis of the disease related to immune response, oxidative stress and coagulation disorders in acute phase. © 2013 Elsevier B.V.en
dc.description.affiliationDepartment of Animal Science Universidade do Estado de Santa Catarina (UDESC), Chapecó, SC
dc.description.affiliationDepartment of Veterinary Clinical and Surgery Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista (UNESP), Jaboticabal, SP
dc.description.affiliationMedicine Veterinary Instituto Federal Catarinense, Concórdia, SC
dc.description.affiliationDepartment of Veterinary Pathology Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista (UNESP), Jaboticabal, SP
dc.description.affiliationDepartamento de Bioquímica Instituto de Ciências Básicas da Saúde Universidade Federal do Rio Grande do Sul, Porto Alegre, RS
dc.description.affiliationAnimal Science Graduate Program Universidade do Estado de Santa Catarina (UDESC), Lages, SC
dc.description.affiliationUnespDepartment of Veterinary Clinical and Surgery Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista (UNESP), Jaboticabal, SP
dc.description.affiliationUnespDepartment of Veterinary Pathology Faculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista (UNESP), Jaboticabal, SP
dc.format.extent602-606
dc.identifierhttp://dx.doi.org/10.1016/j.vetmic.2013.06.033
dc.identifier.citationVeterinary Microbiology, v. 166, n. 3-4, p. 602-606, 2013.
dc.identifier.doi10.1016/j.vetmic.2013.06.033
dc.identifier.issn0378-1135
dc.identifier.issn1873-2542
dc.identifier.scopus2-s2.0-84883290177
dc.identifier.urihttp://hdl.handle.net/11449/76882
dc.identifier.wosWOS:000324960200033
dc.language.isoeng
dc.relation.ispartofVeterinary Microbiology
dc.relation.ispartofjcr2.524
dc.relation.ispartofsjr1,175
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAdenosine
dc.subjectAdenosine deaminase
dc.subjectCanine
dc.subjectEhrlichia canis
dc.subjectadenosine
dc.subjectadenosine deaminase
dc.subjectadenosine diphosphate
dc.subjectadenosine phosphate
dc.subjectadenosine triphosphate
dc.subjecthypoxanthine
dc.subjectpurine
dc.subjecturic acid
dc.subjectxanthine
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectblood level
dc.subjectcanine ehrlichiosis
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectdog
dc.subjectenzyme activity
dc.subjectexperimental infection
dc.subjectnonhuman
dc.subjectpathogenesis
dc.subjectprotein expression
dc.subjectAnimalia
dc.subjectCanis familiaris
dc.titleInfluence of experimental canine ehrlichiosis on the E-ADA activity and purine levels in serum and possible functional correlations with pathogenesisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.orcid0000-0003-0294-9650[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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