Experimental endocrine therapies promote epithelial cytodifferentiation and ciliogenesis in the gerbil female prostate

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dc.contributor.authorAlcantara Santos, Fernanda Cristina
dc.contributor.authorFalleiros-Junior, Luiz Roberto
dc.contributor.authorCorradi, Lara Silvia
dc.contributor.authorLeite Vilamaior, Patricia Simone
dc.contributor.authorTaboga, Sebastiao Roberto
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUNIRP
dc.date.accessioned2014-05-20T14:00:29Z
dc.date.available2014-05-20T14:00:29Z
dc.date.issued2007-06-01
dc.description.abstractThe incidence of ciliated cells in the prostate gland of the female gerbil (Meriones unguiculatus) is uncommon and apparently becomes more frequent during androgen (testosterone cypionate) and anti-estrogen (letrozole) endocrine therapies. To evaluate the effects of such drug therapies on the induction of ciliogenesis in the glandular epithelium of female prostate glands, adult female gerbils aged 90 days were treated for 14 days with testosterone and letrozole after which their prostate glands were removed for histological, ultrastructural, and serological analyses. The cytodifferentiation of the ciliated phenotype in the alveolar epithelium became more frequent after both the testosterone and the letrozole treatments. The ciliogenesis phenomenon of the epithelial cells in the prostate gland of female gerbils thus appears to be induced by variations in the increase of androgen levels.en
dc.description.affiliationUNESP, IBILCE, Dept Biol, BR-15084000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Cell Biol, BR-13083864 Campinas, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, IBILCE, Dept Biol,Microscopy & Microanal Lab, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUNIRP, Rio Preto Univ Ctr, Sch Biol Sci, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespUNESP, IBILCE, Dept Biol, BR-15084000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, IBILCE, Dept Biol,Microscopy & Microanal Lab, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
dc.format.extent617-624
dc.identifierhttp://dx.doi.org/10.1007/s00441-007-0381-y
dc.identifier.citationCell and Tissue Research. New York: Springer, v. 328, n. 3, p. 617-624, 2007.
dc.identifier.doi10.1007/s00441-007-0381-y
dc.identifier.issn0302-766X
dc.identifier.lattes1445259468526188
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.urihttp://hdl.handle.net/11449/21399
dc.identifier.wosWOS:000246178300015
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofCell and Tissue Research
dc.relation.ispartofjcr3.043
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectfemale prostatept
dc.subjectciliogenesispt
dc.subjecttestosteronept
dc.subjectletrozolept
dc.subjectepitheliumpt
dc.subjectMongolian gerbil, Meriones unguiculatus (Rodentia)pt
dc.titleExperimental endocrine therapies promote epithelial cytodifferentiation and ciliogenesis in the gerbil female prostateen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes1445259468526188
unesp.author.orcid0000-0001-9559-5497[4]
unesp.author.orcid0000-0002-0970-4288[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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Artigos - Biologia - IBILCE
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