The enigmatic role of cholinergic reflex in the pathogenesis of Chagas disease

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dc.contributor.authorD'Elia Zanella, Luiz G. F. de A. B.
dc.contributor.authorChies, Agnaldo Bruno
dc.contributor.authorSpadella, Maria Angelica
dc.contributor.authorSilva Therezo, Altino Luiz
dc.contributor.authorRossignoli, Patrícia de Souza [UNESP]
dc.contributor.authorFrei, Fernando [UNESP]
dc.contributor.authorAlves Martins, Luciamare Perinetti
dc.contributor.institutionFaculdade de Medicina de Marília (FAMEMA)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:10:28Z
dc.date.available2014-12-03T13:10:28Z
dc.date.issued2014-06-01
dc.description.abstractThis study evaluated the inflammatory process in the colons of mice infected with Trypanosoma cruzi QM2 strain, through the analysis of muscle reactivity and the measurement of butyrylcholinesterase (BuChE) in plasma. Swiss mice were infected with T. cruzi QM2 strain and after 15 (G15), 30 (G30), 60 (G60), 90 (G90), and 210 (G210) days, each group had blood collected for the measurement of butyrylcholinesterase plasma concentrations ([BuChE]), a measure which functioned as an indicator of plasmatic Ach levels. All groups, except G15, had a segment of proximal colon removed to assess muscle reactivity to acetylcholine (Ach) and noradrenaline (NA) stimulation. After reactivity tests, the tissues were then fixed and stained with hematoxylin and eosin (HE) for histological evaluation of inflammatory response. The QM2 strain did induce inflammatory process in mice colon, and demonstrated differences in muscular contraction between the G60 and G210 groups, with p < 0.05. Plasma [BuChE] increased during the acute phase of infection (p < 0.05) with subsequent heterogeneous decline in the late chronic phase. These results show that the QM2 strain has tropism to the colon of mice and causes damage characteristic of megacolon; also, Ach has an enigmatic importance in the anti-inflammatory reflex over the course of T. cruzi infection.en
dc.description.affiliationMarilia Med Sch, Dept Parasitol, BR-17519100 Marilia, SP, Brazil
dc.description.affiliationMarilia Med Sch, Dept Pharmacol, BR-17519100 Marilia, SP, Brazil
dc.description.affiliationMarilia Med Sch, Dept Embryol, BR-17519100 Marilia, SP, Brazil
dc.description.affiliationMarilia Med Sch, Dept Pathol, BR-17519100 Marilia, SP, Brazil
dc.description.affiliationSao Paulo State Univ, Dept Physiotherapy & Occupat Therapy, Marilia, SP, Brazil
dc.description.affiliationState Univ Sao Paulo, Dept Biol, Assis, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dept Physiotherapy & Occupat Therapy, Marilia, SP, Brazil
dc.description.affiliationUnespState Univ Sao Paulo, Dept Biol, Assis, SP, Brazil
dc.description.sponsorshipLaboratory of Biochemistry-Hemocenter of Marilia Medical School
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent2113-2120
dc.identifierhttp://dx.doi.org/10.1007/s00436-014-3861-5
dc.identifier.citationParasitology Research. New York: Springer, v. 113, n. 6, p. 2113-2120, 2014.
dc.identifier.doi10.1007/s00436-014-3861-5
dc.identifier.issn0932-0113
dc.identifier.lattes2622975453563085
dc.identifier.orcid0000-0001-6946-1145
dc.identifier.urihttp://hdl.handle.net/11449/112157
dc.identifier.wosWOS:000336422600014
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofParasitology Research
dc.relation.ispartofjcr2.558
dc.relation.ispartofsjr0,991
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAcetylcholineen
dc.subjectAnti-inflammatory reflexen
dc.subjectButyrylcholinesteraseen
dc.subjectT. cruzi infectionen
dc.subjectMegacolonen
dc.titleThe enigmatic role of cholinergic reflex in the pathogenesis of Chagas diseaseen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes2622975453563085[5]
unesp.author.orcid0000-0002-3354-8430[6]
unesp.author.orcid0000-0001-6946-1145[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Filosofia e Ciências, Maríliapt

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