Hyperlipidemia as a risk factor of renal allograft function impairment

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dc.contributor.authorCarvalho, MFC
dc.contributor.authorSoares, V
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:21:21Z
dc.date.available2014-05-20T15:21:21Z
dc.date.issued2001-02-01
dc.description.abstractIn this study, the graft outcome in renal allograft recipients with [high cholesterol group (HCG), n = 30] or without [normal cholesterol group (NCG), n = 42] hypercholesterolemia and with [high triglyceride group (HTG), n = 33] or without [normal triglyceride group (NTG), n = 36] hypertriglyceridemia were prospectively compared. At 6 months post-transplantation, no significant difference was observed between the groups (NTG compared with HTG, and NCG compared with HCG) regarding age, presence of arterial hypertension, kind of donor (living related or cadaveric), immunosuppressive therapy, number of rejection episodes per patient, frequency of patients with acute cellular rejection, prevalence of patients with diabetes mellitus or proteinuria > 3 g/24 h, and mean serum creatinine. The probability of doubling serum creatinine during follow-up was statistically different between NTG and HTG (12 months: NTG = 0.03, HTG = 0.15; 36 months: NTG = 0.08, HTG = 0.33; 60 months: NTG = 0.08, HTG = 0.48; and 120 months: NTG = 0.18, HTG = 0.48), but not between NCG and HCG (12 months: NCG = 0.05, HCG = 0.13; 36 months: NCG = 0.13, HCG = 0.24; 60 months: NCG = 0.19, HCG = 0.31; 84 months: NCG = 0.27, HCG = 0.31). There was no significant difference in actuarial graft survival between HCG and NCG or between NTG and HTG. Hypertriglyceridemia, but not hypercholesterolemia, was associated with loss of graft function.en
dc.description.affiliationUNESP, Botucatu Med Sch, Dept Internal Med, Div Nephrol, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Botucatu Med Sch, Dept Internal Med, Div Nephrol, Botucatu, SP, Brazil
dc.format.extent48-52
dc.identifierhttp://dx.doi.org/10.1034/j.1399-0012.2001.150108.x
dc.identifier.citationClinical Transplantation. Copenhagen: Munksgaard Int Publ Ltd, v. 15, n. 1, p. 48-52, 2001.
dc.identifier.doi10.1034/j.1399-0012.2001.150108.x
dc.identifier.issn0902-0063
dc.identifier.urihttp://hdl.handle.net/11449/32512
dc.identifier.wosWOS:000166651700008
dc.language.isoeng
dc.publisherMunksgaard Int Publ Ltd
dc.relation.ispartofClinical Transplantation
dc.relation.ispartofjcr1.518
dc.relation.ispartofsjr0,767
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdyslipidemiapt
dc.subjecthypercholesterolemiapt
dc.subjecthypertriglyceridemiapt
dc.subjectkidney transplantationpt
dc.subjectrenal allograftpt
dc.titleHyperlipidemia as a risk factor of renal allograft function impairmenten
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderMunksgaard Int Publ Ltd
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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