Expression of beta-human chorionic gonadotropin (beta-hCG) in non-trophoblastic elements of transitional cell carcinoma of the bladder: possible relationship with the prognosis.

Página do item simplificado
dc.contributor.authorBacchi, C. E.
dc.contributor.authorCoelho, Kunie Iabuki Rabello [UNESP]
dc.contributor.authorGoldberg, José [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:17:53Z
dc.date.available2014-05-27T11:17:53Z
dc.date.issued1993-05-01
dc.description.abstractTransitional cell carcinoma (TCC) of the bladder is a neoplasm with variability in its clinical behavior. Although there are several studies correlating stage and ABO isoantigen expression with invasiveness, there is no single predictor factor to assess the potential invasiveness, especially in the low grade, non-invasive TCC. In the present study we evaluated the correlation of histological grade plus stage and the expression of beta human chorionic gonadotropin (beta-hCG), in 100 cases of TCC, with the clinical behavior. These features were correlated with tumor progression in patients with at least two years of follow up. We observed more aggressiveness in G4 group (high grade and invasive) (93% had tumor progression) when compared to G1 group (low grade and superficial) (11% had tumor progression). However in 25.5% of the TCC cases (groups G2: low grade and invasive and G3: high grade and superficial) the clinical behavior was intermediate, showing some limitation in using grading and staging only, as a predictive factor. There was an expression of beta-hCG in 21.4% of the cases in up to 25% of the tumor cells without any trophoblastic morphology. These beta-hCG producing TCC had a strong correlation with aggressiveness: 39.1% and 12.8% of the TCC expressed beta-hCG with and without tumor progression, respectively.en
dc.format.extent412-416
dc.identifier.citationRevista Paulista de Medicina, v. 111, n. 3, p. 412-416, 1993.
dc.identifier.issn0035-0362
dc.identifier.scopus2-s2.0-0027588940
dc.identifier.urihttp://hdl.handle.net/11449/64372
dc.language.isoeng
dc.relation.ispartofRevista Paulista de Medicina
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectchorionic gonadotropin
dc.subjectadult
dc.subjectaged
dc.subjectbladder tumor
dc.subjectcancer invasion
dc.subjectcancer staging
dc.subjectchemistry
dc.subjectcomparative study
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjectimmunochemistry
dc.subjectmale
dc.subjectpathology
dc.subjectprognosis
dc.subjecttransitional cell carcinoma
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectBladder Neoplasms
dc.subjectCarcinoma, Transitional Cell
dc.subjectChorionic Gonadotropin
dc.subjectComparative Study
dc.subjectFemale
dc.subjectFollow-Up Studies
dc.subjectHuman
dc.subjectImmunochemistry
dc.subjectMale
dc.subjectMiddle Age
dc.subjectNeoplasm Invasiveness
dc.subjectNeoplasm Staging
dc.subjectPrognosis
dc.titleExpression of beta-human chorionic gonadotropin (beta-hCG) in non-trophoblastic elements of transitional cell carcinoma of the bladder: possible relationship with the prognosis.en
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/spmj/paboutj.htm#03
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

Arquivos

Coleções

Artigos - Patologia - FMB
Artigos - Urologia - FMB