A compatibility study between rice starch and some non-steroidal anti-inflammatories

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dc.contributor.authorFerreira, Beatriz B. [UNESP]
dc.contributor.authorda C. Holanda, Bruno B. [UNESP]
dc.contributor.authorLacerda, Luiz G.
dc.contributor.authorSchnitzler, Egon
dc.contributor.authorVieira, Renata L.D.
dc.contributor.authorGaglieri, Caroline [UNESP]
dc.contributor.authorBannach, Gilbert [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionState University of Ponta Grossa
dc.date.accessioned2021-06-25T11:11:12Z
dc.date.available2021-06-25T11:11:12Z
dc.date.issued2021-04-01
dc.description.abstractThe objective of this work was to mix three milled drugs – Ibuprofen, Naproxen, and Ketoprofen – with rice starch in different proportions and then evaluate its use as an excipient. Differential scanning calorimetry and X-ray powder diffraction verified that the starch was amorphized after the milling process. The samples exhibited similar thermal decomposition profiles, as observed by thermogravimetry. In addition, mid-infrared spectroscopy elucidated the milling process did not alter the functional groups of the starch or the drugs, even in the presence of ethanol. The morphology of the starch granules, as observed by the scanning electron microscope, confirmed decreased particles size and only a physical mixture for the systems. The presence of ethanol in the milling process did not influence the properties of starch or the active ingredients. Therefore, rice starch can be considered as an efficient excipient for these drugs.en
dc.description.affiliationUNESP–São Paulo State University School of Sciences Chemistry Department
dc.description.affiliationState University of Ponta Grossa, Av. Carlos Cavalcanti, 4748
dc.description.affiliationUnespUNESP–São Paulo State University School of Sciences Chemistry Department
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2017/08820–8
dc.description.sponsorshipIdCNPq: 301857/2018–0
dc.identifierhttp://dx.doi.org/10.1016/j.tca.2021.178888
dc.identifier.citationThermochimica Acta, v. 698.
dc.identifier.doi10.1016/j.tca.2021.178888
dc.identifier.issn0040-6031
dc.identifier.scopus2-s2.0-85100412324
dc.identifier.urihttp://hdl.handle.net/11449/208377
dc.language.isoeng
dc.relation.ispartofThermochimica Acta
dc.sourceScopus
dc.subjectExcipient
dc.subjectIbuprofen
dc.subjectKetoprofen
dc.subjectNaproxen
dc.subjectRice starch
dc.titleA compatibility study between rice starch and some non-steroidal anti-inflammatoriesen
dc.typeArtigo
unesp.author.orcid0000-0003-1003-3597[1]
unesp.author.orcid0000-0002-8790-5069[7]

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