In vitro study of cyclosporine A 0.05 % on primary and recurrent pterygium fibroblasts

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dc.contributor.authorViveiros, Magda Massae Hata [UNESP]
dc.contributor.authorKakizaki, Fabiano Yutaka [UNESP]
dc.contributor.authorHércules, Laura Almeida [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorCandeias, João Manuel Grisi [UNESP]
dc.contributor.authorSchellini, Silvana Artioli [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:36:51Z
dc.date.available2015-12-07T15:36:51Z
dc.date.issued2015-08-11
dc.description.abstractTo compare the cyclosporine 0.05 % exposure effect on fibroblasts from primary and recurrent pterygium. Primary culture of fibroblasts from primary and recurrent pterygium was performed until the third passage, which was exposed to cyclosporine 0.05 % in a group and the other remaining unexposed (control group), in triplicates. After 3, 6, 12, and 17 days of exposure the viable cell counting was performed by hemocytometer. The results were statistically analyzed using the technique of analysis of non-parametric variance model for repeated measures with three factors. There was a significant reduction in both fibroblast proliferation, in primary as in the recurrent pterygium cultures exposed to cyclosporine when compared not exposed cultures, with statistical significance (P < 0.05). Comparing primary and recurrent pterygium that received the drug, there was no significant difference in cell proliferation in relation to primary or recurrent pterygium. Cyclosporine 0.05 % is effective in inhibiting fibroblast proliferation in culture, both in primary and as in recurrent pterygium.en
dc.description.affiliationPost-Doctoral of the General Basis of Surgery Post Graduation Program of Botucatu Medical School, Universidade Estadual Paulista - UNESP de Botucatu, São Paulo, Brazil, magdahata@yahoo.com.
dc.description.affiliationUnespPost-Doctoral of the General Basis of Surgery Post Graduation Program of Botucatu Medical School, Universidade Estadual Paulista - UNESP de Botucatu, São Paulo, Brazil, magdahata@yahoo.com.
dc.identifierhttp://dx.doi.org/10.1007/s10792-015-0106-2
dc.identifier.citationInternational Ophthalmology, 2015.
dc.identifier.doi10.1007/s10792-015-0106-2
dc.identifier.issn1573-2630
dc.identifier.lattes9420249100835492
dc.identifier.lattes8727897080522289
dc.identifier.orcid0000-0003-1515-702X
dc.identifier.pubmed26260358
dc.identifier.urihttp://hdl.handle.net/11449/131520
dc.language.isoeng
dc.publisherInternational Ophthalmology
dc.relation.ispartofInternational Ophthalmology
dc.relation.ispartofsjr0,598
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectCyclosporineen
dc.subjectPterygiumen
dc.subjectFibroblastsen
dc.subjectIn vitroen
dc.titleIn vitro study of cyclosporine A 0.05 % on primary and recurrent pterygium fibroblastsen
dc.typeArtigo
unesp.author.lattes9420249100835492
unesp.author.lattes8727897080522289[4]
unesp.author.orcid0000-0003-1515-702X[5]
unesp.author.orcid0000-0002-7719-9682[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Bioestatística - IBB
Artigos - Microbiologia e Imunologia - IBB
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