Report of a chimeric origin of transposable elements in a bovine-coding gene

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dc.contributor.authorAlmeida, L. M. [UNESP]
dc.contributor.authorAmaral, M. E J [UNESP]
dc.contributor.authorSilva, I. T.
dc.contributor.authorSilva, W. A.
dc.contributor.authorRiggs, P. K.
dc.contributor.authorCarareto, C. M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionTexas A and M University
dc.date.accessioned2014-05-27T11:23:32Z
dc.date.available2014-05-27T11:23:32Z
dc.date.issued2008-04-22
dc.description.abstractDespite the wide distribution of transposable elements (TEs) in mammalian genomes, part of their evolutionary significance remains to be discovered. Today there is a substantial amount of evidence showing that TEs are involved in the generation of new exons in different species. In the present study, we searched 22,805 genes and reported the occurrence of TE-cassettes in coding sequences of 542 cow genes using the RepeatMasker program. Despite the significant number (542) of genes with TE insertions in exons only 14 (2.6%) of them were translated into protein, which we characterized as chimeric genes. From these chimeric genes, only the FAST kinase domains 3 (FASTKD3) gene, present on chromosome BTA 20, is a functional gene and showed evidence of the exaptation event. The genome sequence analysis showed that the last exon coding sequence of bovine FASTKD3 is ∼85% similar to the ART2A retrotransposon sequence. In addition, comparison among FASTKD3 proteins shows that the last exon is very divergent from those of Homo sapiens, Pan troglodytes and Canis familiares. We suggest that the gene structure of bovine FASTKD3 gene could have originated by several ectopic recombinations between TE copies. Additionally, the absence of TE sequences in all other species analyzed suggests that the TE insertion is clade-specific, mainly in the ruminant lineage. ©FUNPEC-RP.en
dc.description.affiliationDepartamento de Biologia IBILCE Universidade do Estado de São Paulo, São José do Rio Preto, SP
dc.description.affiliationDepartamento de Genética Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, Ribeirão Preto, SP
dc.description.affiliationDepartment of Animal Science Texas A and M University, College Station, TX
dc.description.affiliationUnespDepartamento de Biologia IBILCE Universidade do Estado de São Paulo, São José do Rio Preto, SP
dc.format.extent107-116
dc.identifierhttp://www.geneticsmr.com//year2008/vol7-1/pdf/gmr371.pdf
dc.identifier.citationGenetics and Molecular Research, v. 7, n. 1, p. 107-116, 2008.
dc.identifier.file2-s2.0-40749141628.pdf
dc.identifier.issn1676-5680
dc.identifier.lattes0175083848055466
dc.identifier.lattes3425772998319216
dc.identifier.orcid0000-0002-0298-1354
dc.identifier.scopus2-s2.0-40749141628
dc.identifier.urihttp://hdl.handle.net/11449/70390
dc.language.isoeng
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCow
dc.subjectDomestication
dc.subjectExaptation
dc.subjectFASTKD3
dc.subjectGenome
dc.subjectTransposon
dc.subjectamino acid sequence
dc.subjectanimal
dc.subjectcattle
dc.subjectchimera
dc.subjectexon
dc.subjectfemale
dc.subjectgenetics
dc.subjectgenome
dc.subjectmolecular evolution
dc.subjectmolecular genetics
dc.subjectprotein tertiary structure
dc.subjectsequence homology
dc.subjecttransposon
dc.subjectchromosome
dc.subjectcladistics
dc.subjectcow
dc.subjectFASTKD3 gene
dc.subjectgene
dc.subjectgene cassette
dc.subjectgene insertion
dc.subjectgene sequence
dc.subjectgene structure
dc.subjectgenetic recombination
dc.subjecthuman
dc.subjectmammal
dc.subjectnonhuman
dc.subjectnucleotide sequence
dc.subjectretroposon
dc.subjectsequence analysis
dc.subjectAmino Acid Sequence
dc.subjectAnimals
dc.subjectCattle
dc.subjectChimera
dc.subjectDNA Transposable Elements
dc.subjectEvolution, Molecular
dc.subjectExons
dc.subjectFemale
dc.subjectMolecular Sequence Data
dc.subjectProtein Structure, Tertiary
dc.subjectSequence Homology, Amino Acid
dc.subjectgene product
dc.subjectprotein FASTKD3
dc.subjectunclassified drug
dc.subjectBovinae
dc.subjectCanis
dc.subjectHomo sapiens
dc.subjectMammalia
dc.subjectPan troglodytes
dc.titleReport of a chimeric origin of transposable elements in a bovine-coding geneen
dc.typeArtigo
dcterms.licensehttp://www.geneticsmr.com/node/5
unesp.author.lattes0175083848055466
unesp.author.lattes3425772998319216[6]
unesp.author.orcid0000-0002-0298-1354[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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