Polymorphism analysis in genes of the somatotropic axis in Nellore cattle selected for growth

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dc.contributor.authorCardoso, Diercles Francisco [UNESP]
dc.contributor.authorPablos de Souza, Fabio Ricardo [UNESP]
dc.contributor.authorFerreira de Camargo, Gregorio Miguel [UNESP]
dc.contributor.authorSilva Fonseca, Patricia Dias da [UNESP]
dc.contributor.authorSimielli Fonseca, Larissa Fernanda [UNESP]
dc.contributor.authorBraz, Camila Urbano [UNESP]
dc.contributor.authorBoligon, Arione Augusti [UNESP]
dc.contributor.authorZerlotti Mercadante, Maria Eugenia
dc.contributor.authorAlbuquerque, Lucia Galvao de [UNESP]
dc.contributor.authorTonhati, Humberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Zootecnia
dc.date.accessioned2014-12-03T13:09:10Z
dc.date.available2014-12-03T13:09:10Z
dc.date.issued2014-07-25
dc.description.abstractThe somatotropic axis consists of genes that are involved in muscular development. These genes are potential regions of study to identify possible QTL for economically important traits in beef cattle. The aim of this study was to verify the existence of GH1, POU1F1, and GHR polymorphisms in Nellore cattle to verify the influence of selection in these mutations and to analyse the association between molecular markers and body weight at different ages, yearling hip height, carcass fat thickness and loin eye area Six hundred forty-five animals from the Centro APTA Bovinos de Corte, were genotyped by PCR-RFLP techniques. The association analyses were performed with general mixed models taking into consideration the effect of one marker, and other model taking into consideration interactions between two molecular markers. Only the molecular markers rs81109601 on GH1 and rs109136815 on GHR were polymorphic; however, they were not found to be under selection. The association of the GHR rs109136815 marker and loin eye area was observed (p < 0.05), as well as the effect of interaction between the markers and the female body weight at 550 days of age (p < 0.04). The interaction effect should be considered in situations where the interactivity between two genes is known. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationSao Paulo State Univ, Jaboticabal, SP, Brazil
dc.description.affiliationInst Zootecnia, Ctr APTA Bovinos Corte, Sertaozinho, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Jaboticabal, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 10/04505-1
dc.format.extent215-219
dc.identifierhttp://dx.doi.org/10.1016/j.gene.2014.05.033
dc.identifier.citationGene. Amsterdam: Elsevier Science Bv, v. 545, n. 2, p. 215-219, 2014.
dc.identifier.doi10.1016/j.gene.2014.05.033
dc.identifier.issn0378-1119
dc.identifier.lattes7445254960858159
dc.identifier.urihttp://hdl.handle.net/11449/112022
dc.identifier.wosWOS:000337867400005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofGene
dc.relation.ispartofjcr2.498
dc.relation.ispartofsjr1,019
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectGHen
dc.subjectGHRen
dc.subjectMolecular markersen
dc.subjectPOU1F1en
dc.subjectSNPen
dc.titlePolymorphism analysis in genes of the somatotropic axis in Nellore cattle selected for growthen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes7445254960858159
unesp.author.orcid0000-0002-2030-7590[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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