The oldest unvaccinated Covid-19 survivors in South America
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2022-12-01
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Background: Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Results: Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN. Conclusion: These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.
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Covid-19, Elderly, SARS-CoV-2, Supercentenarians
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Immunity and Ageing, v. 19, n. 1, 2022.