The oldest unvaccinated Covid-19 survivors in South America

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dc.contributor.authorde Castro, Mateus V.
dc.contributor.authorSilva, Monize V. R.
dc.contributor.authorNaslavsky, Michel S.
dc.contributor.authorScliar, Marilia O.
dc.contributor.authorNunes, Kelly
dc.contributor.authorPassos-Bueno, Maria Rita
dc.contributor.authorCastelli, Erick C. [UNESP]
dc.contributor.authorMagawa, Jhosiene Y.
dc.contributor.authorAdami, Flávia L.
dc.contributor.authorMoretti, Ana I. S.
dc.contributor.authorde Oliveira, Vivian L.
dc.contributor.authorBoscardin, Silvia B.
dc.contributor.authorCunha-Neto, Edecio
dc.contributor.authorKalil, Jorge
dc.contributor.authorJouanguy, Emmanuelle
dc.contributor.authorBastard, Paul
dc.contributor.authorCasanova, Jean-Laurent
dc.contributor.authorQuiñones-Vega, Mauricio
dc.contributor.authorSosa-Acosta, Patricia
dc.contributor.authorde Guedes, Jéssica S.
dc.contributor.authorde Almeida, Natália P.
dc.contributor.authorNogueira, Fábio C. S.
dc.contributor.authorDomont, Gilberto B.
dc.contributor.authorSantos, Keity S.
dc.contributor.authorZatz, Mayana
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionInstituto de Investigação em Imunologia-Instituto Nacional de Ciências e Tecnologia-iii-INCT
dc.contributor.institutionNecker Hospital for Sick Children
dc.contributor.institutionUniversity of Paris
dc.contributor.institutionThe Rockefeller University
dc.contributor.institutionFederal University of Rio de Janeiro
dc.date.accessioned2023-07-29T13:59:40Z
dc.date.available2023-07-29T13:59:40Z
dc.date.issued2022-12-01
dc.description.abstractBackground: Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated. Results: Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN. Conclusion: These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.en
dc.description.affiliationHuman Genome and Stem Cell Research Center University of São Paulo
dc.description.affiliationDepartment of Genetics and Evolutionary Biology Biosciences Institute University of São Paulo
dc.description.affiliationDepartment of Pathology School of Medicine UNESP - São Paulo State University
dc.description.affiliationLaboratório de Imunologia Instituto do Coração (InCor) LIM19 Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP)
dc.description.affiliationInstituto de Investigação em Imunologia-Instituto Nacional de Ciências e Tecnologia-iii-INCT
dc.description.affiliationDepartamento de Clínica Médica Disciplina de Imunologia Clínica e Alergia Faculdade de Medicina da Universidade de São Paulo
dc.description.affiliationLaboratory of Antigen Targeting to Dendritic Cells Department of Parasitology Institute of Biomedical Sciences University of São Paulo
dc.description.affiliationLaboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children
dc.description.affiliationImagine Institute University of Paris
dc.description.affiliationSt. Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University
dc.description.affiliationProteomics Unit Department of Biochemistry Institute of Chemistry Federal University of Rio de Janeiro
dc.description.affiliationLaboratory of Proteomics (LabProt) Institute of Chemistry LADETEC Federal University of Rio de Janeiro
dc.description.affiliationUnespDepartment of Pathology School of Medicine UNESP - São Paulo State University
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 465434/2014-2
dc.identifierhttp://dx.doi.org/10.1186/s12979-022-00310-y
dc.identifier.citationImmunity and Ageing, v. 19, n. 1, 2022.
dc.identifier.doi10.1186/s12979-022-00310-y
dc.identifier.issn1742-4933
dc.identifier.scopus2-s2.0-85142189171
dc.identifier.urihttp://hdl.handle.net/11449/249002
dc.language.isoeng
dc.relation.ispartofImmunity and Ageing
dc.sourceScopus
dc.subjectCovid-19
dc.subjectElderly
dc.subjectSARS-CoV-2
dc.subjectSupercentenarians
dc.titleThe oldest unvaccinated Covid-19 survivors in South Americaen
dc.typeArtigo

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Artigos - Microbiologia e Imunologia - IBB