Periodontal disease severity in subjects with dementia: A systematic review and meta-analysis

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dc.contributor.authorGusman, David Jonathan R. [UNESP]
dc.contributor.authorMello-Neto, João M. [UNESP]
dc.contributor.authorAlves, Breno Edson S. [UNESP]
dc.contributor.authorMatheus, Henrique R. [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorTheodoro, Letícia H. [UNESP]
dc.contributor.authorde Almeida, Juliano M. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:36:08Z
dc.date.available2018-12-11T17:36:08Z
dc.date.issued2018-05-01
dc.description.abstractBackground and objective: Despite clinical trials and reviews attempt to assess a possible relationship between dementia and periodontal disease, no meta-analysis has been performed and this issue remains undetermined. The aim of this study is to conduct a systematic review and meta-analysis to assess severity of periodontitis in subjects with dementia. Methods: The search was conducted in Pubmed, Embase/MEDLINE. Two independent reviewers extracted data and assessed the risk bias (Newcastle–Ottawa scale). Meta-analyses were performed using the means of probing depth (PD) and clinical attachment loss (CAL) in patients with or without dementia. The mean difference were analyzed (P ≤ 0.05). Results: Fourteen studies were included in the systematic review. In the qualitative analysis, most studies reported higher prevalence of periodontal disease in dementia patients. The studies had low risk of bias and two meta-analyses were performed for each parameter, including or not a cross-sectional study. The meta-analyses including the cross-sectional study demonstrated significant association between dementia and periodontal disease (mean difference: PD = 1.41; CAL = 1.40, P < 0.05), however, it wasn't confirmed when the cross-sectional study was removed (1.25 mm, P < 0.22) and CAL (1.20 mm, P < 0.22). Conclusion: Although the qualitative analysis have suggested worse periodontal conditions in dementia patients, due to different study types and the high heterogeneity among them, the meta-analysis does not support the association between dementia and severity of periodontal disease.en
dc.description.affiliationDepartment of Surgery and Integrated Clinic Division of Periodontics São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationDepartment of Basic Sciences São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationUnespDepartment of Surgery and Integrated Clinic Division of Periodontics São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationUnespDepartment of Basic Sciences São Paulo State University (Unesp) School of Dentistry
dc.format.extent147-159
dc.identifierhttp://dx.doi.org/10.1016/j.archger.2018.02.016
dc.identifier.citationArchives of Gerontology and Geriatrics, v. 76, p. 147-159.
dc.identifier.doi10.1016/j.archger.2018.02.016
dc.identifier.file2-s2.0-85042879681.pdf
dc.identifier.issn1872-6976
dc.identifier.issn0167-4943
dc.identifier.lattes4408095517346846
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.scopus2-s2.0-85042879681
dc.identifier.urihttp://hdl.handle.net/11449/179634
dc.language.isoeng
dc.relation.ispartofArchives of Gerontology and Geriatrics
dc.relation.ispartofsjr1,010
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDementia
dc.subjectMeta-analysis
dc.subjectPeriodontal disease
dc.subjectSystematic review
dc.titlePeriodontal disease severity in subjects with dementia: A systematic review and meta-analysisen
dc.typeResenha
unesp.author.lattes4408095517346846[5]
unesp.author.orcid0000-0003-0071-1630[7]
unesp.author.orcid0000-0003-4859-0583[5]

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