Effects of swimming training on the femoral neck strength in growing rats with untreated streptozotocin-induced diabetes

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dc.contributor.authorda Silva, Ana Karina
dc.contributor.authorDel Carlo, Ricardo Junqueira
dc.contributor.authorda Matta, Sérgio Luis Pinto
dc.contributor.authorLouzada, Mario Jefferson Quirino
dc.contributor.authorRodrigues, Aurora Corrêa
dc.contributor.authorda Silva, Márcia Ferreira
dc.contributor.authorDrummond, Lucas Rios
dc.contributor.authorde Castro, Cynthia Aparecida
dc.contributor.authorSilva, Carlos Henrique Osorio
dc.contributor.authorNatali, Antônio José
dc.contributor.institutionFederal University of Vicosa
dc.contributor.institutionFederal University of Viçosa
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-28T19:01:29Z
dc.date.available2022-04-28T19:01:29Z
dc.date.issued2014-12-01
dc.description.abstractBackground: While type 1 diabetes mellitus (T1DM) increases bone fragility physical exercise improves bone quality and strength. Research question: To test whether swimming training attenuates the deterioration of femoral neck structural and mechanical properties in growing rats with untreated streptozotocin (STZ)-induced T1DM. Type of study: Randomised controlled study. Methods: Male Wistar rats (4-weeks-old; initial body weight: 80-90 g) were divided into 4 groups of 10 animals: diabetes sedentary (DS; 60 mg/kg of STZ, single i.p.); diabetes exercised (DE; 60 mg/kg of STZ, single i.p.); control sedentary (CS, same single dose of vehicle); and control exercised (CE, same single dose of vehicle). Six weeks later animals from DE and CE groups underwent a low- intensity swimming training (5 sessions/wk, 90 min/session, load: 4% of body weight) for 8 weeks. The femoral neck mechanical properties were measured. Bone mineral density (BMD) and mineral content (BMC), as well as the femoral neck bone volume (BV/TV) and collagen content were assessed. Results: Rats with T1DM exhibited reduced body weight, femoral weight and length, BMC and BMD, femoral neck collagen content, BV/TV, trabecular thickness, maximum load, stiffness and tenacity, and increased trabecular spacing compared to controls. Swimming training increased femoral BMC and BMD, femoral neck collagen content, BV/TV, trabecular thickness, stiffness and yield point energy, and reduced trabecular spacing in control animals, but not in T1DM animals. Conclusion: Low-intensity swimming training seems to be ineffective in attenuating the deterioration of the femoral neck structural and mechanical properties in growing rats with untreated STZ-induced T1DM.en
dc.description.affiliationDepartment of Physical Education Federal University of Vicosa
dc.description.affiliationDepartment of Veterinary Federal University of Vicosa
dc.description.affiliationDepartment of General Biology Federal University of Viçosa
dc.description.affiliationSchool of Veterinary Medicine State University of São Paulo
dc.description.affiliationDepartment of Statistics Federal University of Vicosa
dc.format.extent445-457
dc.identifier.citationInternational SportMed Journal, v. 15, n. 4, p. 445-457, 2014.
dc.identifier.issn1528-3356
dc.identifier.scopus2-s2.0-84939250656
dc.identifier.urihttp://hdl.handle.net/11449/220426
dc.language.isoeng
dc.relation.ispartofInternational SportMed Journal
dc.sourceScopus
dc.subjectBone resistance
dc.subjectExercise
dc.subjectHip fracture
dc.subjectOsteopenia
dc.subjectPhysical activity
dc.titleEffects of swimming training on the femoral neck strength in growing rats with untreated streptozotocin-induced diabetesen
dc.typeArtigo

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