Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride

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dc.contributor.authorChiba, Fernando Yamamoto [UNESP]
dc.contributor.authorColombo, Natalia Helena [UNESP]
dc.contributor.authorShirakashi, Daisy Jaqueline [UNESP]
dc.contributor.authorde Souza Gomes, Wendrew Douglas [UNESP]
dc.contributor.authorMoimaz, Suzely Adas Saliba [UNESP]
dc.contributor.authorGarbin, Clea Adas Saliba [UNESP]
dc.contributor.authorSilva, Cristina Antoniali [UNESP]
dc.contributor.authorSumida, Doris Hissako [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:29:15Z
dc.date.accessioned2014-05-20T13:43:03Z
dc.date.available2013-09-30T18:29:15Z
dc.date.available2014-05-20T13:43:03Z
dc.date.issued2010-01-01
dc.description.abstractWith half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the insulin receptor substrate (pp185-IRS-1/IRS/2), tyrosine phosphorylation status, and the extent of glycemia and insulinemia. This chronic treatment with F promoted: 1) decrease in the pp185 tyrosine phosphorylation status in the muscle tissue but not in the liver; 2) increase in the plasma F level; 3) no alteration in glycemia and insulinemia; 4) an increase in insulin resistance.en
dc.description.affiliationUniv Estadual Paulista, Dent Sch Aracatuba, Dept Basic Sci, UNESP, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Child & Social Dent, Dent Sch Aracatuba, UNESP, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dent Sch Aracatuba, Dept Basic Sci, UNESP, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Child & Social Dent, Dent Sch Aracatuba, UNESP, BR-16015050 Aracatuba, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 08/52688-8
dc.format.extent25-30
dc.identifierhttp://www.fluorideresearch.org/431a/files/FJ2010_v43_n1_p00i-iii.pdf
dc.identifier.citationFluoride. Ocean View: Int Soc Fluoride Research, v. 43, n. 1, p. 25-30, 2010.
dc.identifier.issn0015-4725
dc.identifier.lattes2799473073030693
dc.identifier.lattes6656433539493879
dc.identifier.lattes8275401688702343
dc.identifier.lattes4419158525709686
dc.identifier.orcid0000-0001-5069-8812
dc.identifier.urihttp://hdl.handle.net/11449/14984
dc.identifier.wosWOS:000278509600005
dc.language.isoeng
dc.publisherInt Soc Fluoride Research
dc.relation.ispartofFluoride
dc.relation.ispartofjcr1.438
dc.relation.ispartofsjr0,429
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectFluorideen
dc.subjectInsulin receptor substrateen
dc.subjectInsulin sensitivityen
dc.subjectInsulin signalen
dc.subjectRats and insulinen
dc.titleInsulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluorideen
dc.typeArtigo
dcterms.rightsHolderInt Soc Fluoride Research
unesp.author.lattes2799473073030693
unesp.author.lattes6656433539493879
unesp.author.lattes8275401688702343
unesp.author.lattes4419158525709686[6]
unesp.author.orcid0000-0001-5069-8812[6]
unesp.author.orcid0000-0003-4406-405X[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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