Effects of uterine cervix constriction on Wistar rats

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dc.contributor.authorRaposo-Amaral, Cassio Eduardo
dc.contributor.authorAlmeida, Ana Beatriz
dc.contributor.authorRaposo-Amaral, Cesar Augusto
dc.contributor.authorVulcano, Luiz Carlos [UNESP]
dc.contributor.authorPassos-Bueno, Maria Rita
dc.contributor.authorAlonso, Nivaldo
dc.contributor.institutionSOBRAPAR
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-29T08:48:22Z
dc.date.available2022-04-29T08:48:22Z
dc.date.issued2010-11-01
dc.description.abstractPurpose: To verify if uterine cerclage can induce craniosynostosis or any cranial deformity in new born Wistar rats. Methods: One pregnant female Wistar rat underwent laparotomy on day 18 of gestation and the uterus cervix was closed with a 3-0 nylon suture to avoid delivery, that occurs normally on the 21 day. The suture was released after 48 hours beyond the normal gestation period. The female rat delivered 11 pups. Six surviving rats from the delivery (group A - constrained group). Two rats were born from another mother and in the same age were used as control group (group B - 2 nonconstrained controls) were allowed to grow. They were sacrificed 1.2 years after their birth all the eight animals. Linear measurement, routine histology and computed tomography of the skull were performed at the time of their death to evaluate the cranial asymmetries by mesurements of the anatomical landmarks of the craniofacial skeleton of the rats on the two groups and compared then. Results: We did not observe statistically significant differences in any of the compared measurements (p>0.05) obtained through the morphologic and radiologic methods. Histologic examinations did not reveal any sign of premature fusion or suture imbrications. Critical decrease in longitudinal body size was noticed as the limbs too in all the animals of group A. Conclusion: Constriction of uterine cervix leads to fetus suffering, even death for a few animals, associated to small body size, but not to craniosynostosis.en
dc.description.affiliationInstitute of Craniofacial and Plastic Surgery SOBRAPAR, Campinas-SP
dc.description.affiliationVeterinary Medicine State University of Sao Paulo (UNESP), Botucatu-SP
dc.description.affiliationDepartment of Genetics and Evolution Biology Institute of Biosciences USP, Sao Paulo
dc.description.affiliationPlastic Surgery Division Department of Surgery USP, Sao Paulo
dc.description.affiliationUnespVeterinary Medicine State University of Sao Paulo (UNESP), Botucatu-SP
dc.format.extent469-474
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502010000600002
dc.identifier.citationActa Cirurgica Brasileira, v. 25, n. 6, p. 469-474, 2010.
dc.identifier.doi10.1590/S0102-86502010000600002
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.scopus2-s2.0-78650505932
dc.identifier.urihttp://hdl.handle.net/11449/231968
dc.language.isoeng
dc.relation.ispartofActa Cirurgica Brasileira
dc.sourceScopus
dc.subjectCerclage, cervical
dc.subjectCraniosynostoses
dc.subjectRats
dc.subjectSurgery, plastic
dc.titleEffects of uterine cervix constriction on Wistar ratsen
dc.typeArtigo

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