Determination of methyldopa in pharmaceutical formulations by combined spot test-diffuse reflectance spectroscopy

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dc.contributor.authorRibeiro, Paulo Roberto S. [UNESP]
dc.contributor.authorPezza, Leonardo [UNESP]
dc.contributor.authorPezza, Helena Redigolo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:21:56Z
dc.date.available2014-05-27T11:21:56Z
dc.date.issued2006-08-09
dc.description.abstractThis paper describes a very simple and rapid quantitative reflectance spot test procedure for the determination of methyldopa in pharmaceutical formulations. This method is based on the complexation reaction of methyldopa with molybdate ions yielding a yellow stable complex on filter paper. Reflectance measurements were carried out at 410 nm. Under optimal conditions, the calibration graphs obtained for methyldopa by plotting the optical density of the reflectance signal (A R) vs. the log of the concentration were linear from 6.30 × 10 -3 to 1.89 × 10 -2 mol L -1, with a correlation coefficient of 0.998. The detection limit was 2.74 × 10 -3 mol L -1 (R.S.D. = 1.02%) for methyldopa. The common excipients used as additives in pharmaceuticals do not interfere in the proposed method. The method was applied to determine metyldopa in commercial pharmaceutical formulations. The results obtained by the proposed method compare favorably with those obtained by an official procedure at 95% confidence level. ©2006 Sociedade Brasileira de Química.en
dc.description.affiliationInstituto de Química Universidade Estadual Paulista, CP 355, 14801-970 Araraquara-SP
dc.description.affiliationUnespInstituto de Química Universidade Estadual Paulista, CP 355, 14801-970 Araraquara-SP
dc.format.extent674-679
dc.identifierhttp://dx.doi.org/10.1590/S0103-50532006000400007
dc.identifier.citationJournal of the Brazilian Chemical Society, v. 17, n. 4, p. 674-679, 2006.
dc.identifier.doi10.1590/S0103-50532006000400007
dc.identifier.file2-s2.0-33746702584.pdf
dc.identifier.issn0103-5053
dc.identifier.lattes5978908591853524
dc.identifier.lattes3192125098361121
dc.identifier.orcid0000-0003-0197-7369
dc.identifier.scieloS0103-50532006000400007
dc.identifier.scopus2-s2.0-33746702584
dc.identifier.urihttp://hdl.handle.net/11449/69028
dc.identifier.wosWOS:000239616800006
dc.language.isoeng
dc.relation.isnodouble70078*
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.relation.ispartofjcr1.444
dc.relation.ispartofsjr0,357
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDiffuse reflectance
dc.subjectMethyldopa
dc.subjectPharmaceuticals formulations
dc.titleDetermination of methyldopa in pharmaceutical formulations by combined spot test-diffuse reflectance spectroscopyen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/jbchs/iaboutj.htm
unesp.author.lattes5978908591853524
unesp.author.lattes3192125098361121
unesp.author.orcid0000-0003-0197-7369[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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