Cytokine polymorphisms, their influence and levels in Brazilian patients with pulmonary tuberculosis during antituberculosis treatment

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dc.contributor.authorPeresi, Eliana [UNESP]
dc.contributor.authorOliveira, Larissa Ragozo Cardoso [UNESP]
dc.contributor.authorSilva, Weber Laurentino da
dc.contributor.authorCosta, Erika Alessandra Pellison Nunes da [UNESP]
dc.contributor.authorAraujo, João Pessoa [UNESP]
dc.contributor.authorAyres, Jairo Aparecido [UNESP]
dc.contributor.authorFortes, Maria Rita Parise [UNESP]
dc.contributor.authorGraviss, Edward A.
dc.contributor.authorPereira, Ana Carla [UNESP]
dc.contributor.authorCalvi, Sueli Aparecida [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Lauro de Souza Lima
dc.contributor.institutionThe Methodist Hospital Research Institute
dc.date.accessioned2015-12-07T15:30:17Z
dc.date.available2015-12-07T15:30:17Z
dc.date.issued2013
dc.description.abstractCytokines play an essential role during active tuberculosis disease and cytokine genes have been described in association with altered cytokine levels. Therefore, the aim of this study was to verify if IFNG, IL12B, TNF, IL17A, IL10, and TGFB1 gene polymorphisms influence the immune response of Brazilian patients with pulmonary tuberculosis (PTB) at different time points of antituberculosis treatment (T1, T2, and T3). Our results showed the following associations: IFNG +874 T allele and IFNG +2109 A allele with higher IFN- γ levels; IL12B +1188 C allele with higher IL-12 levels; TNF -308 A allele with higher TNF- α plasma levels in controls and mRNA levels in PTB patients at T1; IL17A A allele at rs7747909 with higher IL-17 levels; IL10 -819 T allele with higher IL-10 levels; and TGFB1 +29 CC genotype higher TGF- β plasma levels in PTB patients at T2. The present study suggests that IFNG +874T/A, IFNG +2109A/G, IL12B +1188A/C, IL10 -819C/T, and TGFB1 +21C/T are associated with differential cytokine levels in pulmonary tuberculosis patients and may play a role in the initiation and maintenance of acquired cellular immunity to tuberculosis and in the outcome of the active disease while on antituberculosis treatment.en
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Doenças Tropicais e Diagnóstico por Imagem, Faculdade de Medicina de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Microbiologia e Imunologia, Instituto de Biociências de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Enfermagem, Faculdade de Medicina de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Dermatologia e Radioterapia, Faculdade de Medicina de Botucatu
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.identifierhttp://dx.doi.org/10.1155/2013/285094
dc.identifier.citationTuberculosis Research And Treatment, v. 2013, 2013.
dc.identifier.doi10.1155/2013/285094
dc.identifier.filePMC3619634.pdf
dc.identifier.issn2090-150X
dc.identifier.lattes8459981107789709
dc.identifier.lattes2179450022699059
dc.identifier.pmcPMC3619634
dc.identifier.pubmed23634300
dc.identifier.urihttp://hdl.handle.net/11449/130938
dc.language.isoeng
dc.relation.ispartofTuberculosis Research And Treatment
dc.rights.accessRightsAcesso aberto
dc.sourcePubMed
dc.titleCytokine polymorphisms, their influence and levels in Brazilian patients with pulmonary tuberculosis during antituberculosis treatmenten
dc.typeArtigo
unesp.author.lattes8459981107789709
unesp.author.lattes2179450022699059
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Doenças Tropicais e Diagnósticos por Imagem - FMB
Artigos - Dermatologia e Radioterapia - FMB
Artigos - Enfermagem - FMB
Artigos - Microbiologia e Imunologia - IBB