Interactions of Paracoccidioides brasiliensis with host cells: recent advances

Página do item simplificado
dc.contributor.authorMendes-Giannini, Maria José Soares [UNESP]
dc.contributor.authorMonteiro da Silva, Juliana Leal [UNESP]
dc.contributor.authorda Silva, Julhiany de Fatima [UNESP]
dc.contributor.authorDonofrio, Fabiana Cristina [UNESP]
dc.contributor.authorMiranda, Elaine Toscano [UNESP]
dc.contributor.authorAndreotti, Patricia Ferrari [UNESP]
dc.contributor.authorSoares, Christiane Pienna [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:23:56Z
dc.date.available2014-05-20T13:23:56Z
dc.date.issued2008-04-01
dc.description.abstractHost-fungal interactions are inherently complex and dynamic. In order to identify new microbial targets and develop more effective anti-fungal therapies, it is important to understand the cellular and molecular mechanisms of disease. Paracoccidioidomycosis provokes a variety of clinical symptoms, and Paracoccidioides brasiliensis can reach many tissues, but primarily attacks the lungs. The ability of the pathogen to interact with the host surface structures is essential to further colonization, invasion, and growth. Epithelial cells may represent the first host barrier or the preferential site of entry of the fungus. For this reason, interactions between P. brasiliensis and Vero/A549 epithelial cells were evaluated, with an emphasis on the adherence, induction of cytoskeletal alterations, and differential signaling activity of the various surface molecules. The adhesion to and invasion of epithelial cells by P. brasiliensis may represent strategies employed to thwart the initial host immune response, and may help in the subsequent dissemination of the pathogen throughout the body.en
dc.description.affiliationUNESP, Dept Anal Clin, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Anal Clin, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.format.extent237-248
dc.identifierhttp://dx.doi.org/10.1007/s11046-007-9074-z
dc.identifier.citationMycopathologia. Dordrecht: Springer, v. 165, n. 4-5, p. 237-248, 2008.
dc.identifier.doi10.1007/s11046-007-9074-z
dc.identifier.issn0301-486X
dc.identifier.lattes1768025290373669
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.urihttp://hdl.handle.net/11449/7309
dc.identifier.wosWOS:000255256100006
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofMycopathologia
dc.relation.ispartofjcr1.476
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectParacoccidioides brasiliensisen
dc.subjecthost-fungal interactionen
dc.subjectadhesionen
dc.subjectcytoskeletonen
dc.subjectapoptosisen
dc.subjectvirulence factorsen
dc.titleInteractions of Paracoccidioides brasiliensis with host cells: recent advancesen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes1768025290373669[7]
unesp.author.orcid0000-0002-8059-0826[1]
unesp.author.orcid0000-0003-1740-7360[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

Arquivos

Licença do Pacote
Agora exibindo 1 - 2 de 2
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Artigos - Análises Clínicas - FCFAR