Collagen fiber reorganization in the rat ventral prostate following androgen deprivation: A possible role for smooth muscle cells

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dc.contributor.authorVilamaior, Patrcia S. L.
dc.contributor.authorFelisbino, Srgio L.
dc.contributor.authorTaboga, Sebastio R. [UNESP]
dc.contributor.authorCarvalho, Hernandes F.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:19:58Z
dc.date.available2014-05-27T11:19:58Z
dc.date.issued2000-11-20
dc.description.abstractBACKGROUND. Stroma plays an essential role in glandular function in different systems. In the prostate, it is responsible for the development and maintenance of the differentiated state of the epithelium. The marked reduction in the epithelial compartment of the prostate gland following castration is followed by a similarly important reorganization of the stroma. In this work, we characterized the reorganization of collagen fibers in the ventral prostate of castrated rats. METHODS. Histochemical tests and immunohistochemistry for type I and III collagens plus confocal microscopy of triple-labeled (collagen III, actin, and DNA) tissue sections were employed. RESULTS. We showed that collagen fibers are composed of type I and type III collagens and that they are progressively concentrated around the epithelial structures (ducts and acini) and become increasingly undulated and folded. Double-labeling of collagen fibers and F-actin demonstrated that smooth muscle cells (SMC) are intimately associated with collagen fibers. CONCLUSIONS. The results demonstrated a marked reorganization of the collagen fibers, and suggest an active role of the SMC in the reorganization of the fibrillar components of the stroma. (C) 2000 Wiley-Liss, Inc.en
dc.description.affiliationDepartment of Cell Biology UNICAMP, Campinas, So Paulo
dc.description.affiliationDepartment of Biology UNESP, So Jos do Rio Preto, So Paulo
dc.description.affiliationDepartment of Cell Biology UNICAMP CP6109, 13083-970 Campinas, So Paulo
dc.description.affiliationUnespDepartment of Biology UNESP, So Jos do Rio Preto, So Paulo
dc.format.extent253-258
dc.identifierhttp://dx.doi.org/10.1002/1097-0045(20001101)45:3<253::AID-PROS8>3.0.CO;2-P
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1002/1097-0045%2820001101%2945:3%3C253::AID-PROS8%3E3.0.CO;2-P/abstract
dc.identifier.citationProstate, v. 45, n. 3, p. 253-258, 2000.
dc.identifier.doi10.1002/1097-0045(20001101)45:3<253::AID-PROS8>3.0.CO;2-P
dc.identifier.issn0270-4137
dc.identifier.lattes7066358123790434
dc.identifier.orcid0000-0001-9559-5497
dc.identifier.scopus2-s2.0-0033768369
dc.identifier.urihttp://hdl.handle.net/11449/66287
dc.identifier.wosWOS:000165058100008
dc.language.isoeng
dc.relation.ispartofProstate
dc.relation.ispartofjcr3.347
dc.relation.ispartofsjr1,440
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCastration
dc.subjectHistochemistry
dc.subjectPolarizing microscope
dc.subjectRemodelling
dc.subjectStroma
dc.subjectandrogen
dc.subjectcollagen fiber
dc.subjectcollagen type 1
dc.subjectcollagen type 2
dc.subjectF actin
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectcastration
dc.subjectconfocal microscopy
dc.subjectcontrolled study
dc.subjectepithelium
dc.subjecthistochemistry
dc.subjectimmunohistochemistry
dc.subjectpriority journal
dc.subjectprostate ventral lobe
dc.subjectsmooth muscle fiber
dc.subjectstroma
dc.subjectCell Differentiation
dc.subjectCollagen
dc.subjectImmunohistochemistry
dc.subjectMuscle, Smooth
dc.subjectProstate
dc.subjectRats, Wistar
dc.titleCollagen fiber reorganization in the rat ventral prostate following androgen deprivation: A possible role for smooth muscle cellsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.author.lattes7066358123790434[1]
unesp.author.orcid0000-0001-9559-5497[1]
unesp.author.orcid0000-0002-0970-4288[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt

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