Corrective effects of acerola (Malpighia emarginata DC.) juice intake on biochemical and genotoxical parameters in mice fed on a high-fat diet

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dc.contributor.authorLeffa, Daniela Dimer
dc.contributor.authorSilva, Juliana da
dc.contributor.authorDaumann, Francine
dc.contributor.authorFormentin Dajori, Ana Luiza
dc.contributor.authorLongaretti, Luiza Martins
dc.contributor.authorDamiani, Adriani Paganini
dc.contributor.authorLira, Fabio de [UNESP]
dc.contributor.authorCampos, Fernanda
dc.contributor.authorFalcao Ferraz, Alexandre de Barros
dc.contributor.authorCorrea, Dione Silva
dc.contributor.authorAndrade, Vanessa Moraes de
dc.contributor.institutionUniv Southern Santa Catarina
dc.contributor.institutionUniv Luterana Brasil
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:53:42Z
dc.date.available2015-03-18T15:53:42Z
dc.date.issued2014-12-01
dc.description.abstractAcerola contains high levels of vitamin C and rutin and shows the corresponding antioxidant properties. Oxidative stress on the other hand is an important factor in the development of obesity. In this study, we investigated the biochemical and antigenotoxic effects of acerola juice in different stages of maturity (unripe, ripe and industrial) and its main pharmacologically active components vitamin C and rutin, when given as food supplements to obese mice. Initial HPLC analyses confirmed that all types of acerola juice contained high levels of vitamin C and rutin. DPPH tests quantified the antioxidant properties of these juices and revealed higher antioxidant potentials compared to pure vitamin C and rutin. In an animal test series, groups of male mice were fed on a standard (STA) or a cafeteria (CAF) diet for 13 weeks. The latter consisted of a variety of supermarket products, rich in sugar and fat. This CAF diet increased the feed efficiency, but also induced glucose intolerance and DNA damage, which was established by comet assays and micronucleus tests. Subsequently, CAF mice were given additional diet supplements (acerola juice, vitamin C or rutin) for one month and the effects on bone marrow, peripheral blood, liver, kidney, and brain were examined. The results indicated that food supplementation with ripe or industrial acerola juice led to a partial reversal of the diet-induced DNA damage in the blood, kidney, liver and bone marrow. For unripe acerola juice food supplementation, beneficial effects were observed in blood, kidney and bone marrow. Food supplementation with vitamin C led to decreased DNA damage in kidney and liver, whereas rutin supplementation led to decreased DNA damage in all tissue samples observed. These results suggest that acerola juice helps to reduce oxidative stress and may decrease genotoxicity under obesogenic conditions. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Southern Santa Catarina, UNESC, Dept Hlth Sci, Lab Mol & Cellular Biol,Grad Programme Hlth Sci, BR-88806000 Criciuma, SC, Brazil
dc.description.affiliationUniv Luterana Brasil, ULBRA, Postgrad Programme Cellular & Mol Biol Appl Hlth, Lab Toxicol Genet, BR-92425900 Canoas, RS, Brazil
dc.description.affiliationSao Paulo State Univ, UNESP, Dept Phys Educ, BR-01049010 Presidente Prudente, SP, Brazil
dc.description.affiliationUniv Luterana Brasil, ULBRA, Postgrad Programme Cellular & Mol Biol Appl Hlth, Lab Pharmacognosis & Phytochem, BR-92425900 Canoas, RS, Brazil
dc.description.affiliationUniv Luterana Brasil, ULBRA, Postgrad Programme Cellular & Mol Biol Appl Hlth, Lab Instrumental Anal, BR-92425900 Canoas, RS, Brazil
dc.description.affiliationUnespSao Paulo State Univ, UNESP, Dept Phys Educ, BR-01049010 Presidente Prudente, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipUniversity of Southern Santa Catarina (UNESC)
dc.description.sponsorshipLutheran University of Brazil (ULBRA)
dc.format.extent144-152
dc.identifierhttp://dx.doi.org/10.1016/j.mrfmmm.2013.11.005
dc.identifier.citationMutation Research-fundamental And Molecular Mechanisms Of Mutagenesis. Amsterdam: Elsevier Science Bv, v. 770, p. 144-152, 2014.
dc.identifier.doi10.1016/j.mrfmmm.2013.11.005
dc.identifier.issn0027-5107
dc.identifier.urihttp://hdl.handle.net/11449/116672
dc.identifier.wosWOS:000345647400018
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMutation Research-fundamental And Molecular Mechanisms Of Mutagenesis
dc.relation.ispartofjcr2.398
dc.relation.ispartofsjr0,111
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCafeteria dieten
dc.subjectMalpighia emarginataen
dc.subjectComet assayen
dc.subjectMicronucleus testen
dc.subjectVitamin Cen
dc.subjectRutinen
dc.titleCorrective effects of acerola (Malpighia emarginata DC.) juice intake on biochemical and genotoxical parameters in mice fed on a high-fat dieten
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0003-2094-2903[1]
unesp.author.orcid0000-0002-1089-6766[2]
unesp.author.orcid0000-0002-8474-4482[11]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Tecnologia, Presidente Prudentept

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