Gingival crevicular fluid levels of human beta-defensin 1 in individuals with and without chronic periodontitis

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dc.contributor.authorCosta, L. C.M.
dc.contributor.authorSoldati, K. R. [UNESP]
dc.contributor.authorFonseca, D. C.
dc.contributor.authorCosta, J. E.
dc.contributor.authorAbreu, M. H.N.G.
dc.contributor.authorCosta, F. O.
dc.contributor.authorZandim-Barcelos, D. L. [UNESP]
dc.contributor.authorCota, L. O.M.
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity Center of Lavras-UNILAVRAS
dc.date.accessioned2018-12-11T16:55:23Z
dc.date.available2018-12-11T16:55:23Z
dc.date.issued2018-10-01
dc.description.abstractBackground and Objective: Human beta-defensins (hBDs) contribute to innate immunity antimicrobial activity. They are also effective in the adaptive immune response and may play a crucial role in the susceptibility to diseases of the oral cavity. This study aimed to evaluate the levels of hBD-1 in the gingival crevicular fluid of individuals with and without chronic periodontitis. Material and Methods: Twenty periodontally healthy individuals (H) and 20 individuals with chronic periodontitis were recruited. Gingival crevicular fluid samples were collected from: healthy sites (Hh) from periodontally healthy individuals; and healthy sites (Ph), sites with gingivitis (Pg), and sites with periodontitis (Pp) from individuals with periodontitis. The levels of hBD-1 (pg/mL) were measured using enzyme-linked immunosorbent assay. Comparisons of hBD-1 between individuals (H and chronic periodontitis) and among sites (Hh, Ph, Pg, Pp) were performed through hierarchical linear modeling. Results: Gingival crevicular fluid levels of hBD-1 were: Hh = 229.52 ± 138.96 (median 199.26), Ph = 53.88 ± 58.17 (median 35.75), Pg = 57.11 ± 40.18 (median 39.90) and Pp = 55.31 ± 37.28 (median 54.19). No influence of site diagnosis (level 1; health/gingivitis/periodontitis) was observed; however, individual diagnosis (level 2; health/periodontitis) influenced the levels of hBD-1 (P <.001). Conclusion: Periodontally healthy individuals showed higher gingival crevicular fluid levels of hBD-1 when compared to individuals with chronic periodontitis. This suggests a potential protective role of hBD-1 in the susceptibility to chronic periodontitis.en
dc.description.affiliationDepartment of Dental Clinics Oral Pathology and Oral Surgery School of Dentistry Federal University of Minas Gerais- UFMG
dc.description.affiliationDepartament of Diagnosis and Surgery School of Dentistry São Paulo State University-UNESP
dc.description.affiliationDepartment of Dentistry University Center of Lavras-UNILAVRAS
dc.description.affiliationDepartment of Community and Preventive Dentistry School of Dentistry Federal University of Minas Gerais-UFMG
dc.description.affiliationUnespDepartament of Diagnosis and Surgery School of Dentistry São Paulo State University-UNESP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.format.extent736-742
dc.identifierhttp://dx.doi.org/10.1111/jre.12558
dc.identifier.citationJournal of Periodontal Research, v. 53, n. 5, p. 736-742, 2018.
dc.identifier.doi10.1111/jre.12558
dc.identifier.issn1600-0765
dc.identifier.issn0022-3484
dc.identifier.scopus2-s2.0-85053246741
dc.identifier.urihttp://hdl.handle.net/11449/171450
dc.language.isoeng
dc.relation.ispartofJournal of Periodontal Research
dc.relation.ispartofsjr0,927
dc.relation.ispartofsjr0,927
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectbeta-defensins
dc.subjectchronic periodontitis
dc.subjectELISA (enzyme-linked immunosorbent assay)
dc.subjectgingival crevicular fluid
dc.titleGingival crevicular fluid levels of human beta-defensin 1 in individuals with and without chronic periodontitisen
dc.typeArtigo
unesp.author.orcid0000-0002-7687-1238[6]
unesp.author.orcid0000-0003-1517-5842[8]

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