Administration of physiologic levels of triiodothyronine increases leptin expression in calorie-restricted obese rats, but does not influence weight loss

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dc.contributor.authorLuvizotto, Renata A. M. [UNESP]
dc.contributor.authorConde, Sandro J. [UNESP]
dc.contributor.authorSibio, Maria T. [UNESP]
dc.contributor.authorNascimento, Andre F. [UNESP]
dc.contributor.authorLima-Leopoldo, Ana P. [UNESP]
dc.contributor.authorLeopoldo, Andre S. [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.contributor.authorNogueira, Célia Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:33:21Z
dc.date.available2014-05-20T13:33:21Z
dc.date.issued2010-01-01
dc.description.abstractObesity has become a major public health problem, most commonly treated via dietary restriction to promote weight loss. Although leptin and thyroid hormones are involved in the regulation of energy balance, the role of these hormones after the stabilization of weight loss remains unclear. This study was designed to analyze the effect of thyroid hormone on sustained weight loss and leptin gene expression in obese animals after a loss of 5% to 10% of body weight. Thirty-day old male Wistar rats were separated into 4 groups: control, obese, calorie restriction (CR), and calorie restriction with triiodothyronine administration (CRT). The obese group had increased weight and adiposity, leptin and insulin levels, and leptin gene expression. Dietary restriction in the CR group resulted in decreased body weight and adiposity, diminished leptin, and increased thyroid hormone receptor beta expression. The CRT group, submitted to dietary restriction with concomitant administration of a physiologic triiodothyronine dose, had thyroid hormone receptor beta expression at levels comparable with those observed in the control group and simultaneously increased leptin expression as compared with that in the CR group, suggesting that thyroid hormone modulates leptin expression under conditions of calorie restriction. Increased leptin expression in the CRT group did not result in increased circulating leptin or a statistically significant reduction in body weight during the treatment period. These data provide impetus for further study, as a longer treatment period may result in increased circulating leptin and, thus, further reduction in body weight during calorie restriction in an obesity model. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo State UNESP, Botucatu Sch Med, Dept Clin Med, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv São Paulo State UNESP, Inst Biol Sci, Dept Biostat, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv São Paulo State UNESP, Botucatu Sch Med, Dept Clin Med, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv São Paulo State UNESP, Inst Biol Sci, Dept Biostat, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1-6
dc.identifierhttp://dx.doi.org/10.1016/j.metabol.2009.06.017
dc.identifier.citationMetabolism-clinical and Experimental. Philadelphia: W B Saunders Co-elsevier Inc, v. 59, n. 1, p. 1-6, 2010.
dc.identifier.doi10.1016/j.metabol.2009.06.017
dc.identifier.issn0026-0495
dc.identifier.lattes9418970103564137
dc.identifier.lattes8727897080522289
dc.identifier.urihttp://hdl.handle.net/11449/11412
dc.identifier.wosWOS:000276761500001
dc.language.isoeng
dc.publisherW B Saunders Co-elsevier Inc
dc.relation.ispartofMetabolism-clinical and Experimental
dc.relation.ispartofjcr5.963
dc.relation.ispartofsjr2,285
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleAdministration of physiologic levels of triiodothyronine increases leptin expression in calorie-restricted obese rats, but does not influence weight lossen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderW B Saunders Co-elsevier Inc
unesp.author.lattes9418970103564137[8]
unesp.author.lattes8727897080522289[7]
unesp.author.lattes7607038776901890[9]
unesp.author.orcid0000-0003-1876-5418[2]
unesp.author.orcid0000-0002-7354-9518[9]
unesp.author.orcid0000-0002-7719-9682[7]
unesp.author.orcid0000-0002-4402-6523[8]
unesp.author.orcid0000-0002-4014-0660[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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