Effects of exposure to ethanolic extract from Achyrocline satureioides (Lam.) D.C. flowers on reproductive and developmental parameters in Wistar rats

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dc.contributor.authorMaciel, Marcela Dias
dc.contributor.authorInocêncio, Leonardo Cesar Lima [UNESP]
dc.contributor.authorRechsteiner, Mayra Schmidt [UNESP]
dc.contributor.authorJorge, Barbara Campos [UNESP]
dc.contributor.authorBalin, Paola da Silva [UNESP]
dc.contributor.authorKassuya, Roberto Mikio
dc.contributor.authorHeredia-Vieira, Silvia Cristina
dc.contributor.authorCardoso, Claudia Andrea Lima
dc.contributor.authorVieira, Maria do Carmo
dc.contributor.authorKassuya, Cândida Aparecida Leite
dc.contributor.authorArena, Arielle Cristina [UNESP]
dc.contributor.institutionFederal University of Grande Dourados
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAnhanguera Faculty of Dourados
dc.contributor.institutionUniversidade Estadual de Mato Grosso do Sul (UEMS)
dc.date.accessioned2019-10-06T16:23:23Z
dc.date.available2019-10-06T16:23:23Z
dc.date.issued2019-03-04
dc.description.abstractAchyrocline satureioides (LAM) D.C. is a species plant used in folk medicine with several medicinal properties; however, few studies have focused on its potential adverse effects. The aim of this study was to examine the effects of ethanolic extract of A. satureioides flowers administered during pre-mating, mating, pregnancy and postpartum period on reproductive and developmental parameters in rats. Male and female rats received by gavage 0, 250, 500 or 750 mg/kg of extract. The animals were treated from pre-mating until 13 days post-partum. Phytochemical analysis revealed the presence of important flavonoids (quercetin, luteolin, caffeic acid, rutin, and ferulic acid). In females, biochemical, hematological or gestational parameters were not markedly altered by the extract. However, an increase in calcium and thyroid stimulating hormone (TSH) levels was found in treated-dams. Although TSH and T4 levels were not significantly altered in pups, there was a rise in body weight of pups whose mothers were treated with the extract. All males treated were able to successfully copulate with treated-females. However, rats exposed to 500 and 750 mg/kg of extract exhibited a significant decrease in daily testicular sperm production and delay in sperm transit time in the epididymis. The ethanolic extract of A. satureioides flowers produced adverse effects in the male reproductive system as evidenced by diminished sperm production and transport. In addition, the extract elevated TSH levels of exposed mothers which may consequently affect the development of pups but this requires further evaluation.en
dc.description.affiliationSchool of Health Sciences Federal University of Grande Dourados
dc.description.affiliationDepartment of Morphology Institute of Biosciences of Botucatu UNESP –São Paulo State University Estadual Paulista
dc.description.affiliationAnhanguera Faculty of Dourados
dc.description.affiliationCenter of Studies on Natural Resources Mato Grosso do Sul State University (UEMS)
dc.description.affiliationUnespDepartment of Morphology Institute of Biosciences of Botucatu UNESP –São Paulo State University Estadual Paulista
dc.format.extent321-330
dc.identifierhttp://dx.doi.org/10.1080/15287394.2019.1593904
dc.identifier.citationJournal of Toxicology and Environmental Health - Part A: Current Issues, v. 82, n. 5, p. 321-330, 2019.
dc.identifier.doi10.1080/15287394.2019.1593904
dc.identifier.issn1087-2620
dc.identifier.issn1528-7394
dc.identifier.scopus2-s2.0-85063720927
dc.identifier.urihttp://hdl.handle.net/11449/188920
dc.language.isoeng
dc.relation.ispartofJournal of Toxicology and Environmental Health - Part A: Current Issues
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAchyrocline satureioides
dc.subjectfertility
dc.subjectoffspring
dc.subjectrats
dc.subjectsubacute toxicity
dc.titleEffects of exposure to ethanolic extract from Achyrocline satureioides (Lam.) D.C. flowers on reproductive and developmental parameters in Wistar ratsen
dc.typeArtigo
unesp.author.lattes0729220781785349[11]
unesp.author.orcid0000-0002-2373-9399[11]

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