Rutin administration attenuates myocardial dysfunction in diabetic rats

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dc.contributor.authorGuimarães, Julliano F. C. [UNESP]
dc.contributor.authorMuzio, Bruno P. [UNESP]
dc.contributor.authorRosa, Camila M. [UNESP]
dc.contributor.authorNascimento, André F. [UNESP]
dc.contributor.authorSugizaki, Mário M. [UNESP]
dc.contributor.authorFernandes, Ana A. H. [UNESP]
dc.contributor.authorCicogna, Antonio C. [UNESP]
dc.contributor.authorPadovani, Carlos R. [UNESP]
dc.contributor.authorOkoshi, Marina P. [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:31:32Z
dc.date.available2015-12-07T15:31:32Z
dc.date.issued2015
dc.description.abstractOxidative stress plays a major role in diabetic cardiomyopathy pathogenesis. Anti-oxidant therapy has been investigated in preventing or treating several diabetic complications. However, anti-oxidant action on diabetic-induced cardiac remodeling is not completely clear. This study evaluated the effects of rutin, a flavonoid, on cardiac and myocardial function in diabetic rats. Wistar rats were assigned into control (C, n = 14); control-rutin (C-R, n = 14); diabetes mellitus (DM, n = 16); and DM-rutin (DM-R, n = 16) groups. Seven days after inducing diabetes (streptozotocin, 60 mg/kg, i.p.), rutin was injected intraperitoneally once a week (50 mg/kg) for 7 weeks. Echocardiogram was performed and myocardial function assessed in left ventricular (LV) papillary muscles. Serum insulin concentration was measured by ELISA. One-way ANOVA and Tukey's post hoc test. Glycemia was higher in DM than DM-R and C and in DM-R than C-R. Insulin concentration was lower in diabetic groups than controls (C 2.45 ± 0.67; C-R 2.09 ± 0.52; DM 0.59 ± 0.18; DM-R 0.82 ± 0.21 ng/mL). Echocardiogram showed no differences between C-R and C. DM had increased LV systolic diameter compared to C, and increased left atrium diameter/body weight (BW) ratio and LV mass/BW ratio compared to C and DM-R. Septal wall thickness, LV diastolic diameter/BW ratio, and relative wall thickness were lower in DM-R than DM. Fractional shortening and posterior wall shortening velocity were lower in DM than C and DM-R. In papillary muscle preparation, DM and DM-R presented higher time to peak tension and time from peak tension to 50% relaxation than controls; time to peak tension was lower in DM-R than DM. Under 0.625 and 1.25 mM extracellular calcium concentrations, DM had higher developed tension than C. Rutin attenuates cardiac remodeling and left ventricular and myocardial dysfunction caused by streptozotocin-induced diabetes mellitus.en
dc.description.affiliationDepartamento de Medicina Interna, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.affiliationDepartamento de Química e Bioquímica, Instituto de Biociências de Botucatu (IBB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.affiliationDepartamento de Clínica Médica, Faculdade de Medicina de Botucatu (FMB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Clínica Médica, Faculdade de Medicina de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Química e Bioquímica, Instituto de Biociências de Botucatu
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipPró-Reitoria de Pesquisa da UNESP (PROPe)
dc.description.sponsorshipIdCNPq: 306845/2012-1
dc.description.sponsorshipIdCNPq: 306857/2012-0)
dc.description.sponsorshipIdFAPESP: 2009/54506-7
dc.format.extent90-96
dc.identifierhttp://dx.doi.org/10.1186/s12933-015-0255-7
dc.identifier.citationCardiovascular Diabetology, v. 14, p. 90-96, 2015.
dc.identifier.doi10.1186/s12933-015-0255-7
dc.identifier.filePMC4504040.pdf
dc.identifier.issn1475-2840
dc.identifier.lattes1590971576309420
dc.identifier.pmcPMC4504040
dc.identifier.pubmed26185015
dc.identifier.urihttp://hdl.handle.net/11449/131093
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofCardiovascular Diabetology
dc.relation.ispartofjcr5.235
dc.relation.ispartofsjr2,157
dc.rights.accessRightsAcesso aberto
dc.sourcePubMed
dc.titleRutin administration attenuates myocardial dysfunction in diabetic ratsen
dc.typeArtigo
dcterms.rightsHolderBioMed Central
unesp.author.lattes1590971576309420
unesp.author.lattes9418970103564137[7]
unesp.author.lattes8727897080522289[8]
unesp.author.orcid0000-0002-4402-6523[7]
unesp.author.orcid0000-0002-7719-9682[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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