Effect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessment

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dc.contributor.authorFerreira, Ana LĂșcia dos Anjos [UNESP]
dc.contributor.authorRussell, Robert Mitchell
dc.contributor.authorRocha, Noeme Sousa [UNESP]
dc.contributor.authorPlacido Ladeira, Marcelo Sady
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorMunhoz Oliveira Nascimento, Maria Carolina
dc.contributor.authorMatsui, Mirna
dc.contributor.authorCarvalho, Flavio Augusto
dc.contributor.authorTang, Guangwen
dc.contributor.authorMatsubara, Luiz Shiguero [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionTufts Univ
dc.date.accessioned2014-05-20T13:37:02Z
dc.date.available2014-05-20T13:37:02Z
dc.date.issued2007-07-01
dc.description.abstractDoxorubicin is an excellent chemotherapeutic agent utilized for several types of cancer but the irreversible doxorubicin-induced cardiac damage is the major limitation for its use. Oxidative stress seems to be associated with some phase of the toxicity mechanism process. To determine if lycopene protects against doxorubicin-induced cardiotoxicity, male Wistar rats were randomly assigned either to control, lycopene, doxorubicin or doxorubicin + lycopene groups. They received corn oil (control, doxorubicin) or lycopene (5 mg/kg body weight a day) (lycopene, doxorubicin + lycopene) by gavage for a 7-week period. They also received saline (control, lycopene) or doxorubicin (4 mg/kg) (doxorubicin, doxorubin + lycopene) intraperitoneally by week 3, 4 5 and 6. Animals underwent echocardiogram and were killed for tissue analyses by week 7. Mean lycopene levels (nmol/kg) in liver were higher in the doxorubicin + lycopene group (5822.59) than in the lycopene group (2496.73), but no differences in lycopene were found in heart or Plasma of these two groups. Lycopene did not prevent left ventricular systolic dysfunction induced by doxorubicin. However, morphologic examination revealed that doxorubicin-induced myocyte damage was significantly suppressed in rats treated with lycopene. Doxorubicin treatment was followed by increase of myocardium interstitial collagen volume fraction. Our results show that: (i) doxorubicin-induced cardiotoxicity was confirmed by echocardiogram and morphological evaluations; (ii) lycopene absorption was confirmed by its levels in heart, liver and plasma; (iii) lycopene supplementation provided myocyte protection without preventing interstitial collagen accumulation increase; (iv) doxorubicin-induced cardiac dysfunction was not prevented by lycopene supplementation; and (v) lycopene depletion was not observed in plasma and tissues from animals treated with doxorubicin.en
dc.description.affiliationUniv Estadual Paulista, Botucatu Fac Med, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Botucatu Fac Med, Dept Pathol, Botucatu, SP, Brazil
dc.description.affiliationTufts Univ, USDA, Human Nutr Res Ctr Aging, Boston, MA 02111 USA
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Fac Med, Dept Internal Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Botucatu Fac Med, Dept Pathol, Botucatu, SP, Brazil
dc.format.extent16-24
dc.identifierhttp://dx.doi.org/10.1111/j.1742-7843.2007.00070.x
dc.identifier.citationBasic & Clinical Pharmacology & Toxicology. Oxford: Blackwell Publishing, v. 101, n. 1, p. 16-24, 2007.
dc.identifier.doi10.1111/j.1742-7843.2007.00070.x
dc.identifier.fileWOS000247681900003.pdf
dc.identifier.issn1742-7835
dc.identifier.lattes2940051650846541
dc.identifier.lattes5051118752980903
dc.identifier.lattes6309835137998766
dc.identifier.lattes6990977122340795
dc.identifier.lattes6077735918469284
dc.identifier.orcid0000-0002-8188-8149
dc.identifier.urihttp://hdl.handle.net/11449/12774
dc.identifier.wosWOS:000247681900003
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofBasic & Clinical Pharmacology & Toxicology
dc.relation.ispartofjcr2.659
dc.relation.ispartofsjr0,655
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleEffect of lycopene on doxorubicin-induced cardiotoxicity: An echocardiographic, histological and morphometrical assessmenten
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderBlackwell Publishing
unesp.author.lattes2940051650846541[1]
unesp.author.lattes5051118752980903
unesp.author.lattes6309835137998766
unesp.author.lattes6990977122340795
unesp.author.lattes6077735918469284
unesp.author.orcid0000-0002-5267-1127[1]
unesp.author.orcid0000-0002-8188-8149
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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