Anti-inflammatory drug design by molecular hybridization approach

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dc.contributor.authorBosquesi, Priscila Longhin [UNESP]
dc.contributor.authorMelo, Tais Regina Ferreira [UNESP]
dc.contributor.authorVizioli, Ednir de Oliveira [UNESP]
dc.contributor.authorSantos, Jean Leandro dos [UNESP]
dc.contributor.authorChung, Man Chin [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-01-28T16:56:31Z
dc.date.available2016-01-28T16:56:31Z
dc.date.issued2011
dc.description.abstractThe design of new drugs with better physiochemical properties, adequateabsorption, distribution, metabolism, and excretion, effective pharmacologic potency andlacking toxicity remains is a challenge. Inflammation is the initial trigger of severaldifferent diseases, such as Alzheimer s disease, asthma, atherosclerosis, colitis, rheumatoidarthritis, depression, cancer; and disorders such as obesity and sexual dysfunction.Although inflammation is not the direct cause of these disorders, inflammatory processesoften increase related pain and suffering. New anti-inflammatory drugs developed usingmolecular hybridization techniques to obtain multiple-ligand drugs can act at one or multipletargets, allowing for synergic action and minimizing toxicity. This work is a review of newanti-inflammatory drugs developed using the molecular modification approach.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Ciências Farmacêuticas de Araraquara (FCFAR), Departamento de Fármacos e Medicamentos, Rodovia Araraquara-Jaú, km 1, Campus Ville, CEP 14801902, Araraquara, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho (UNESP), Faculdade de Ciências Farmacêuticas de Araraquara (FCFAR), Departamento de Fármacos e Medicamentos, Rodovia Araraquara-Jaú, km 1, Campus Ville, CEP 14801902, Araraquara, SP, Brasil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Pesquisa (CNPq)
dc.description.sponsorshipIdFAPESP: 2010/12495-6
dc.description.sponsorshipIdFAPESP: 2010/50330-9
dc.description.sponsorshipIdCNPq: 308157/2010-9
dc.format.extent1450-1474
dc.identifierhttp://dx.doi.org/10.3390/ph4111450
dc.identifier.citationPharmaceuticals, v. 4, p. 1450-1474, 2011.
dc.identifier.doi10.3390/ph4111450
dc.identifier.fileISSN1424-8247-2011-04-1450-1474.pdf
dc.identifier.issn1424-8247
dc.identifier.lattes4083068210623663
dc.identifier.lattes3204277043366119
dc.identifier.lattes5435899068903487
dc.identifier.lattes9734333607975413
dc.identifier.lattes5737933639516944
dc.identifier.orcid0000-0003-4141-0455
dc.identifier.urihttp://hdl.handle.net/11449/133761
dc.language.isoeng
dc.relation.ispartofPharmaceuticals
dc.relation.ispartofsjr1,293
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectAnti-inflammatoryen
dc.subjectHybridizationen
dc.subjectMultiple-ligandsen
dc.subjectMutual prodrugen
dc.titleAnti-inflammatory drug design by molecular hybridization approachen
dc.typeArtigo
unesp.author.lattes4083068210623663
unesp.author.lattes3204277043366119
unesp.author.lattes5435899068903487
unesp.author.lattes5737933639516944
unesp.author.lattes9734333607975413[5]
unesp.author.orcid0000-0003-4141-0455[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentospt

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