Micro and nanosystems for delivering local anesthetics

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dc.contributor.authorde Paula, Eneida
dc.contributor.authorCereda, Cintia M. S.
dc.contributor.authorFraceto, Leonardo F. [UNESP]
dc.contributor.authorde Araujo, Daniele R.
dc.contributor.authorFranz-Montan, Michelle
dc.contributor.authorTofoli, Giovana R.
dc.contributor.authorRanali, Jose
dc.contributor.authorVolpato, Maria C.
dc.contributor.authorGroppo, Francisco C.
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniv Sao Francisco
dc.date.accessioned2014-05-20T13:12:11Z
dc.date.available2014-05-20T13:12:11Z
dc.date.issued2012-12-01
dc.description.abstractIntroduction: One of the most common strategies for pain control during and after surgical procedures is the use of local anesthetics. Prolonged analgesia can be safely achieved with drug delivery systems suitably chosen for each local anesthetic agent.Areas covered: This review considers drug delivery formulations of local anesthetics designed to prolong the anesthetic effect and decrease toxicity. The topics comprise the main drug delivery carrier systems (liposomes, biopolymers, and cyclodextrins) for infiltrative administration of local anesthetics. A chronological review of the literature is presented, including details of formulations as well as the advantages and pitfalls of each carrier system. The review also highlights pharmacokinetic data on such formulations, and gives an overview of the clinical studies published so far concerning pain control in medicine and dentistry.Expert opinion: The design of novel drug delivery systems for local anesthetics must focus on how to achieve higher uploads of the anesthetic into the carrier, and how to sustain its release. This comprehensive review should be useful to provide the reader with the current state-of-art regarding drug delivery formulations for local anesthetics and their possible clinical applications.en
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Biochem, Campinas, SP, Brazil
dc.description.affiliationSão Paulo State Univ Unesp, Dept Environm Engn, Sorocaba, SP, Brazil
dc.description.affiliationABC Fed Univ, Nat & Human Sci Ctr, Santo Andre, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, Piracicaba, SP, Brazil
dc.description.affiliationUniv Sao Francisco, Lab Mol Biol & Pharmacol, BR-12900000 Braganca Paulista, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ Unesp, Dept Environm Engn, Sorocaba, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 06/00121-9
dc.format.extent1505-1524
dc.identifierhttp://dx.doi.org/10.1517/17425247.2012.738664
dc.identifier.citationExpert Opinion on Drug Delivery. London: Informa Healthcare, v. 9, n. 12, p. 1505-1524, 2012.
dc.identifier.doi10.1517/17425247.2012.738664
dc.identifier.issn1742-5247
dc.identifier.urihttp://hdl.handle.net/11449/172
dc.identifier.wosWOS:000311420700006
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofExpert Opinion on Drug Delivery
dc.relation.ispartofjcr5.553
dc.relation.ispartofsjr1,432
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcyclodextrinsen
dc.subjectliposomesen
dc.subjectlocal anestheticsen
dc.subjectmicroparticlesen
dc.subjectnanocapsulesen
dc.subjectnanospheresen
dc.subjectpolymersen
dc.titleMicro and nanosystems for delivering local anestheticsen
dc.typeResenha
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dcterms.rightsHolderInforma Healthcare
unesp.author.orcid0000-0002-9289-4229[4]
unesp.author.orcid0000-0002-1459-7050[8]
unesp.author.orcid0000-0002-2827-2038[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, Sorocabapt

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